Description

(3S)-(-)-3-(Trifluoroacetamido)Pyrrolidine Hydrochloride is a high-purity chiral building block and intermediate of significant importance in advanced organic synthesis. Its value lies in its defined stereochemistry and functional groups, which are critical for constructing complex molecules with specific biological activity. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) targets and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, especially for neurological and psychiatric disorders.
• Asymmetric Synthesis: Used as a building block for constructing complex, enantiomerically pure molecules in medicinal chemistry and process R&D.
• Protease Inhibitor Research: Serves as a core structural component in the design and synthesis of protease inhibitor libraries.
• Chemical Biology & Probe Development: Employed in the creation of molecular probes to study enzyme function and biological pathways.
• Agrochemical Synthesis: Potential intermediate in the development of advanced, chiral agrochemicals with improved efficacy and selectivity.
• Academic Research: Utilized in university and institutional labs for methodological studies in organic chemistry and catalysis.

Basic Information

Item	Details
Product Name	(3S)-(-)-3-(Trifluoroacetamido)Pyrrolidine Hydrochloride
CAS No.	132883-43-3
Molecular Formula	C6H10F3N2O·HCl
Molecular Weight	232.61 g/mol
Synonyms	(3S)-3-(2,2,2-Trifluoroacetamido)pyrrolidine hydrochloride; (S)-3-(Trifluoroacetamido)pyrrolidine HCl; (-)-3-(Trifluoroacetamido)pyrrolidine hydrochloride; (3S)-3-[(Trifluoroacetyl)amino]pyrrolidine hydrochloride; Pyrrolidine, 3-[(trifluoroacetyl)amino]-, hydrochloride, (3S)-; TFA-Pro-NH2·HCl (common abbreviation); (S)-3-Amino-1-(2,2,2-trifluoroacetyl)pyrrolidinium chloride
EINECS	Contact for details

Quality Control

Our (3S)-(-)-3-(Trifluoroacetamido)Pyrrolidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.