Description

6-(Trifluoromethoxy)-1H-Benzimidazol-2-Aminehydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its benzimidazole core and trifluoromethoxy substituent. This compound is of significant commercial importance for its role in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring specific molecular frameworks. It is primarily sought by research institutions and manufacturers in the pharmaceutical and agrochemical industries for the development of new drug candidates and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel benzimidazole-based drug candidates, potentially for antiviral, anticancer, or anti-parasitic applications.
• Agrochemical Research: Used in the development of new generation pesticides and fungicides, leveraging the biological activity of the benzimidazole scaffold.
• Organic Synthesis: Serves as a versatile precursor for further chemical modifications in medicinal chemistry and material science research.
• Biochemical Tool Compound: Employed in life science research as a probe or inhibitor to study specific enzymatic pathways or biological targets.

Basic Information

Product Name	6-(Trifluoromethoxy)-1H-Benzimidazol-2-Aminehydrochloride
CAS No.	132877-28-2
Molecular Formula	C8H7F3N3O·HCl
Molecular Weight	269.62 g/mol
Synonyms	2-Amino-6-(trifluoromethoxy)-1H-benzimidazole hydrochloride; 6-(Trifluoromethoxy)-2-benzimidazolamine hydrochloride; 2-Amino-6-trifluoromethoxybenzimidazole HCl; 1H-Benzimidazol-2-amine, 6-(trifluoromethoxy)-, hydrochloride (1:1); 132877-28-2; 6-Trifluoromethoxy-1H-benzimidazol-2-ylamine hydrochloride
EINECS	Contact for details

Quality Control

Our 6-(Trifluoromethoxy)-1H-Benzimidazol-2-Aminehydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and impurity profiling. Certificates of Analysis (COA) detailing identity, purity, and related substances are provided and available upon request, supporting compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Any individual impurity ≤0.5%; Total impurities ≤2.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.