Description

2-Azabicyclo[3.1.0]Hexane-1-Carboxylic Acid (Hydrochloride) is a high-purity, advanced pharmaceutical intermediate characterized by its unique strained bicyclic structure. This compound is of significant commercial importance for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in the development of central nervous system (CNS) and antiviral therapeutics. It is primarily utilized by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in innovative drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of complex drug molecules, including protease inhibitors and neuromodulators.
• Organic Synthesis Building Block: Used in medicinal chemistry for constructing constrained peptide mimetics and fused ring systems to explore novel chemical space.
• Research & Development: Serves as a valuable scaffold in academic and industrial R&D for studying structure-activity relationships (SAR) and developing new therapeutic candidates.
• Process Chemistry: Employed in the scale-up and optimization of synthetic routes for target molecules in pre-clinical and clinical development stages.

Basic Information

Product Name	2-Azabicyclo[3.1.0]Hexane-1-Carboxylic Acid (Hydrochloride)
CAS No.	132806-41-8
Molecular Formula	C6H9NO2 • HCl
Molecular Weight	163.60 g/mol (Free base: 127.14 g/mol)
Synonyms	1-Azabicyclo[3.1.0]hexane-2-carboxylic acid hydrochloride; (1R,5S)-2-Azabicyclo[3.1.0]hexane-3-carboxylic acid hydrochloride; 2-Azabicyclo[3.1.0]hexane-3-carboxylic acid, hydrochloride; 3-Carboxy-2-azabicyclo[3.1.0]hexane hydrochloride; Bicyclo[3.1.0]hexane-1-carboxylic acid, 2-aza-, hydrochloride
EINECS	Contact for details

Quality Control

Our 2-Azabicyclo[3.1.0]Hexane-1-Carboxylic Acid (Hydrochloride) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.