Description

1-[1-(4-Amino-6,7-Dimethoxy-Quinazolin-2-Yl)-4-Piperidyl]-3H-Benzoimid Azol-2-One Hydrochloride is a high-purity, advanced pharmaceutical intermediate and research chemical with significant therapeutic potential. This compound is valued for its role as a key building block in the synthesis of novel kinase inhibitors and other targeted therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in developing innovative drug candidates.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel tyrosine kinase inhibitors (TKIs) and other targeted cancer therapies.
• Biochemical Research: Used as a reference standard and active compound in enzymatic assays and structure-activity relationship (SAR) studies.
• Drug Discovery: Serves as a core scaffold for medicinal chemists exploring new chemical entities (NCEs) for oncology and other therapeutic areas.
• Preclinical Development: Employed in the formulation of test articles for pharmacokinetic, pharmacodynamic, and toxicology studies.
• Academic Research: Utilized in university and institutional labs for fundamental research on cell signaling pathways and drug mechanisms.
• Custom Synthesis: A starting material for the contract manufacturing of specialized, high-value active pharmaceutical ingredients (APIs).

Basic Information

Product Name	1-[1-(4-Amino-6,7-Dimethoxy-Quinazolin-2-Yl)-4-Piperidyl]-3H-Benzoimid Azol-2-One Hydrochloride
CAS No.	132764-69-3
Molecular Formula	C22H23N7O3 · HCl
Molecular Weight	469.92 g/mol (Free base: 433.46 g/mol)
Synonyms	1-[1-(4-Amino-6,7-dimethoxyquinazolin-2-yl)piperidin-4-yl]-1,3-dihydro-2H-benzimidazol-2-one hydrochloride; 1-(1-(4-Amino-6,7-dimethoxyquinazolin-2-yl)-4-piperidyl)-3H-benzimidazol-2-one HCl; 2-One Hydrochloride, 1-[1-(4-Amino-6,7-Dimethoxy-Quinazolin-2-Yl)-4-Piperidyl]-3H-Benzoimidazol; 132764-69-3; UNII-9J8K3A8U4Q; 9J8K3A8U4Q; Benzoimidazol-2-one derivative hydrochloride
EINECS	Contact for details

Quality Control

Our 1-[1-(4-Amino-6,7-Dimethoxy-Quinazolin-2-Yl)-4-Piperidyl]-3H-Benzoimid Azol-2-One Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals to ensure compliance with research and pharmaceutical intermediate standards. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.