Description

(1S,4S)-2,5-Diazabicyclo[2.2.1]heptane Dihydrobromide is a high-purity, chiral bicyclic diamine salt primarily used as a sophisticated building block in pharmaceutical research and development. Its rigid, three-dimensional structure makes it a valuable scaffold for creating novel active pharmaceutical ingredients (APIs) and chiral ligands for asymmetric synthesis. This compound is essential for medicinal chemists and process development scientists working in drug discovery, particularly for central nervous system (CNS) targets and complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel drug candidates, especially in neurological and psychiatric therapeutic areas.
• Asymmetric Synthesis: Serves as a precursor for chiral ligands and organocatalysts used in enantioselective transformations.
• Chemical Biology Probe Development: Used to create molecular probes for studying enzyme mechanisms and protein-ligand interactions due to its constrained geometry.
• Peptidomimetics: Incorporated into peptide backbones to induce specific conformational restraints and enhance metabolic stability.
• Coordination Chemistry: Acts as a chelating agent for metal ions in catalyst design and materials science.
• Academic & Industrial R&D: Critical for exploratory research in synthetic methodology and medicinal chemistry within university and corporate laboratories.

Basic Information

Product Name	(1S,4S)-2,5-Diazabicyclo[2.2.1]heptane Dihydrobromide
CAS No.	132747-20-7
Molecular Formula	C5H12N2 · 2HBr
Molecular Weight	267.99 g/mol
Synonyms	(1S,4S)-2,5-Diazabicyclo[2.2.1]heptane Hydrobromide (1:2); (1S,4S)-2,5-Diazabicyclo[2.2.1]heptane Dihydrobromide Salt; endo-2,5-Diazabicyclo[2.2.1]heptane Dihydrobromide; (1S,4S)-2,5-Diazabicyclo[2.2.1]heptane, hydrobromide; 2,5-Diazabicyclo[2.2.1]heptane, (1S,4S)-, dihydrobromide; DABCO Derivative Salt
EINECS	Contact for details

Quality Control

Our (1S,4S)-2,5-Diazabicyclo[2.2.1]heptane Dihydrobromide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality system is designed to meet the stringent requirements of pharmaceutical R&D and advanced synthetic chemistry.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.