Description

6-Amino-6-Deoxyfumagillol is a key synthetic intermediate and derivative of the potent angiogenesis inhibitor fumagillin. This compound matters significantly for researchers and manufacturers developing novel therapeutics, particularly in oncology and anti-angiogenic applications. Pharmaceutical R&D teams and fine chemical suppliers need this high-purity building block for the synthesis of targeted drug candidates and for biological activity studies.

Application

• Pharmaceutical Intermediate: Critical building block in the synthesis of novel anti-angiogenic and anti-cancer drug candidates targeting tumor growth.
• Biochemical Research: Used as a reference standard and active compound in studies investigating angiogenesis inhibition and endothelial cell proliferation.
• Medicinal Chemistry: Serves as a versatile scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity of fumagillin analogs.
• API Development: Employed in the research and development stages of new Active Pharmaceutical Ingredients (APIs) for targeted therapies.
• Fine Chemical Synthesis: A specialized intermediate for producing custom, high-value compounds in contract manufacturing and development organizations (CDMOs).

Basic Information

Product Name	6-Amino-6-Deoxyfumagillol
CAS No.	132746-71-5
Molecular Formula	C26H37NO7
Molecular Weight	475.58 g/mol
Synonyms	6-Amino-6-deoxyfumagillol; 6-ADF; 6-Amino-6-deoxy-fumagillol; Fumagillol, 6-amino-6-deoxy-; (3R,4S,5S,6R)-5-Methoxy-4-[(2R,3R)-2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-1-oxaspiro[2.5]octan-6-amine; TNP-470 Intermediate; AGM-1470 Derivative
EINECS	Contact for details

Quality Control

Our 6-Amino-6-Deoxyfumagillol is produced under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical development. We provide comprehensive analytical data, including HPLC purity, identity confirmation (IR, NMR), and impurity profiling. Certificates of Analysis (COA) are available for every batch and supplied upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.