Description

(S)-2-Amino-3-(4-Fluoro-3-Hydroxyphenyl)Propanoic Acid Hydrochloride is a high-purity, non-natural amino acid derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical chiral building block for the synthesis of novel therapeutic agents, particularly those targeting the central nervous system. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the development of peptide-based drugs and enzyme inhibitors.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and synthesis of novel drug candidates, especially for neurological and psychiatric disorders.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate a fluorinated, hydroxylated phenylalanine analogue into peptide chains, modifying their bioactivity and metabolic stability.
• Enzyme Inhibitor Development: Serves as a precursor or core structure for designing inhibitors of enzymes like tyrosine hydroxylase or aromatic amino acid decarboxylase.
• Biochemical Research: Employed as a standard or probe in studies of amino acid transport, metabolism, and receptor-ligand interactions due to its fluorinated aromatic ring.
• Asymmetric Synthesis: Acts as a starting material or chiral auxiliary in the asymmetric synthesis of more complex, biologically active molecules.
• Radiopharmaceutical Precursor: The fluorine atom presents an opportunity for isotopic labeling (e.g., with F-18) for use in Positron Emission Tomography (PET) tracer development.

Basic Information

Product Name	(S)-2-Amino-3-(4-Fluoro-3-Hydroxyphenyl)Propanoic Acid Hydrochloride
CAS No.	132732-79-7
Molecular Formula	C9H10FNO3·HCl
Molecular Weight	235.64 g/mol
Synonyms	(S)-4-Fluoro-3-hydroxy-DL-phenylalanine hydrochloride; (S)-2-Amino-3-(4-fluoro-3-hydroxyphenyl)propionic acid hydrochloride; F-DOPA analogue hydrochloride; (S)-3-(4-Fluoro-3-hydroxyphenyl)alanine HCl; L-4-Fluoro-3-hydroxyphenylalanine hydrochloride; 4-Fluoro-3-hydroxy-L-phenylalanine HCl; 4-F-3-OH-Phe-OH·HCl
EINECS	Contact for details

Quality Control

Every batch of (S)-2-Amino-3-(4-Fluoro-3-Hydroxyphenyl)Propanoic Acid Hydrochloride is manufactured under a quality management system and undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as chiral purity, assay, and related substances. Our quality commitment aligns with the standards expected for pharmaceutical intermediates in research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.