Description

6-Chloro-9-(2,3-Dideoxy-2-Fluoro-β-D-Threo-Pentofuranosyl)-9H-Purine is a high-purity nucleoside analog building block of significant importance in advanced pharmaceutical research and development. Its core value lies in its role as a critical synthetic intermediate for novel antiviral and anticancer therapeutics, particularly in the development of modified nucleoside reverse transcriptase inhibitors. This compound is essential for research institutions, CROs, and pharmaceutical companies engaged in the synthesis of next-generation antiviral agents and exploring novel mechanisms of action in oncology. The precise stereochemistry and halogen substitution make it a valuable scaffold for creating targeted bioactive molecules.

Application

• Pharmaceutical Intermediate: Primary use as a key building block in the synthesis of experimental antiviral drugs, particularly nucleotide analogs.
• Antiviral Research: Serves as a precursor for the development of novel nucleoside reverse transcriptase inhibitors (NRTIs) targeting viruses such as HIV and HBV.
• Oncology Drug Discovery: Utilized in research programs focused on creating purine-based antimetabolites for cancer therapy.
• Biochemical Research: Acts as a substrate or inhibitor in enzymatic studies involving polymerases and other nucleic acid-processing enzymes.
• Prodrug Synthesis: Used in the chemical modification and prodrug development to enhance the bioavailability and targeting of nucleoside therapeutics.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	6-Chloro-9-(2,3-Dideoxy-2-Fluoro-β-D-Threo-Pentofuranosyl)-9H-Purine
CAS No.	132722-95-3
Molecular Formula	C10H10ClFN4O2
Molecular Weight	272.66 g/mol
Synonyms	2'-Fluoro-2',3'-dideoxy-6-chloropurine nucleoside; 6-Chloro-9-(2,3-dideoxy-2-fluoro-β-D-threo-pentofuranosyl)-9H-purine; 2'-F-2',3'-dd-6-Cl-Purine; 6-Chloro-2'-fluoro-2',3'-dideoxypurine; β-D-Threo-pentofuranoside, 6-chloro-9-(2,3-dideoxy-2-fluoro)-9H-purine; 132722-95-3; 6-Cl-2'F-ddPur
EINECS	Contact for details

Quality Control

Our 6-Chloro-9-(2,3-Dideoxy-2-Fluoro-β-D-Threo-Pentofuranosyl)-9H-Purine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent control of residual solvents and impurities to ensure compliance with research and development standards. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.