Description

9-(2-Fluoro-2,3-Dideoxy-β-D-Threo-Pentofuranosyl)-8-Methyl-9H-Purine-6-Amine is a high-purity nucleoside analog building block of significant interest in advanced pharmaceutical research and development. This compound is valued for its role as a key synthetic intermediate in the creation of novel antiviral and anticancer therapeutics. It is primarily utilized by research institutions, pharmaceutical companies, and CDMOs (Contract Development and Manufacturing Organizations) engaged in the synthesis of modified nucleosides and oligonucleotides. Our supply ensures consistent quality and reliable availability for critical R&D and scale-up processes.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel antiviral and anticancer drug candidates.
• Antiviral Research: Used in the development of nucleotide analogs targeting viral polymerases and reverse transcriptases.
• Oncology Research: Serves as a precursor in the creation of chemotherapeutic agents designed to disrupt DNA/RNA synthesis in cancer cells.
• Oligonucleotide Synthesis: Employed in the production of modified antisense oligonucleotides (ASOs) and siRNA constructs for therapeutic applications.
• Biochemical Research: Utilized as a substrate or inhibitor in enzymatic studies to investigate nucleoside metabolism and related pathways.
• Process Development: Supports route scouting and optimization for the scalable manufacturing of active pharmaceutical ingredients (APIs).

Basic Information

Item	Details
Product Name	9-(2-Fluoro-2,3-Dideoxy-β-D-Threo-Pentofuranosyl)-8-Methyl-9H-Purine-6-Amine
CAS No.	132722-94-2
Molecular Formula	C11H14FN5O2
Molecular Weight	267.26 g/mol
Synonyms	8-Methyl-9-(2-fluoro-2,3-dideoxy-β-D-threo-pentofuranosyl)adenine; 2'-Fluoro-2',3'-dideoxy-8-methyladenosine; 9-(2-Fluoro-2,3-dideoxy-β-D-threo-pentofuranosyl)-8-methyladenine; 8-Methyl-2'-F-ddA; 132722-94-2; 8-Methyl-2'-fluoro-2',3'-dideoxyadenosine; 9H-Purine-6-amine, 9-(2-fluoro-2,3-dideoxy-β-D-threo-pentofuranosyl)-8-methyl-
EINECS	Contact for details

Quality Control

Our 9-(2-Fluoro-2,3-Dideoxy-β-D-Threo-Pentofuranosyl)-8-Methyl-9H-Purine-6-Amine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and MS, to ensure it meets the stringent requirements of pharmaceutical research. Certificates of Analysis (COA) with full traceability are available upon request, supporting compliance with internal quality standards and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.