Description

9-(2-Fluoro-2,3-Dideoxy-β-D-Threo-Pentofuranosyl)-N,2-Dimethyl-9H-Purine-6-Amine is a high-purity nucleoside analog of significant interest in advanced pharmaceutical research and development. This compound serves as a critical intermediate or reference standard in the synthesis of novel antiviral and anticancer therapeutics, where precise molecular structure is paramount. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on nucleoside-based drug discovery programs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of next-generation antiviral and anticancer nucleoside analogs.
• Biochemical Research: Used as a reference standard or substrate in enzymatic studies and metabolic pathway investigations.
• Antiviral Drug Development: Serves as a core structural motif in the research of compounds targeting viral polymerases.
• Oncology Research: Investigated for its potential incorporation into prodrugs designed to inhibit cancer cell proliferation.
• Process Chemistry: Employed in scaling up synthetic routes for active pharmaceutical ingredients (APIs) under GMP conditions.
• Analytical Standard: Provides a high-purity benchmark for quality control (HPLC, NMR) in manufacturing and regulatory submissions.

Basic Information

Product Name	9-(2-Fluoro-2,3-Dideoxy-β-D-Threo-Pentofuranosyl)-N,2-Dimethyl-9H-Purine-6-Amine
CAS No.	132722-92-0
Molecular Formula	C₁₂H₁₆FN₅O₃
Molecular Weight	297.29 g/mol
Synonyms	2'-Fluoro-2',3'-dideoxy-N,2-dimethyladenosine; 2'-F-ddA Derivative; 9-(2-Fluoro-2,3-dideoxy-β-D-threo-pentofuranosyl)-N,2-dimethyl-9H-purin-6-amine; 2'-F-2',3'-dd-N,2-Dimethyladenosine; N,2-Dimethyl-2'-fluoro-2',3'-dideoxyadenosine; 132722-92-0; Fluorinated dideoxy nucleoside analog
EINECS	Contact for details

Quality Control

Our 9-(2-Fluoro-2,3-Dideoxy-β-D-Threo-Pentofuranosyl)-N,2-Dimethyl-9H-Purine-6-Amine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles as determined by advanced analytical techniques including HPLC, NMR, and MS. We adhere to relevant industry guidelines to support our customers' regulatory and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and purity. Long-term storage under inert atmosphere (e.g., argon or nitrogen) is recommended for optimal preservation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.