Description

2-(tert-Butoxycarbonylamino)-6-(3-Nitroguanidino)Hexanoic Acid is a specialized, high-purity chemical building block featuring both Boc-protected amine and nitroguanidino functional groups. This compound is critically important for the synthesis of complex molecules, particularly in pharmaceutical research and development. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for creating novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting enzyme inhibition or receptor modulation.
• Peptidomimetic Research: Used to incorporate modified arginine-like structures into peptide backbones to enhance stability, bioavailability, and biological activity.
• Protease Inhibitor Development: Serves as a precursor for compounds designed to inhibit specific proteases involved in various disease pathways.
• Agrochemical Synthesis: Employed in the research and development of new pesticides and herbicides that require guanidine-based bioactive motifs.
• Bioconjugation & Labeling: The reactive functional groups allow for site-specific conjugation in the development of antibody-drug conjugates (ADCs) or diagnostic probes.
• Chemical Biology Tool: Utilized in the design of activity-based probes (ABPs) or affinity labels to study enzyme function and mechanism.

Basic Information

Product Name	2-(tert-Butoxycarbonylamino)-6-(3-Nitroguanidino)Hexanoic Acid
CAS No.	132718-70-8
Molecular Formula	C₁₂H₂₃N₅O₆
Molecular Weight	333.34 g/mol
Synonyms	Boc-Nitroarginine; 2-[(2-Methylpropan-2-yl)oxycarbonylamino]-6-(3-nitroguanidino)hexanoic acid; N2-[(1,1-Dimethylethoxy)carbonyl]-N6-(3-nitroamidino)-L-lysine; Nα-Boc-Nω-nitro-L-arginine; Boc-Nitro-Arg-OH; (S)-2-((tert-Butoxycarbonyl)amino)-6-(3-nitroguanidino)hexanoic acid; N6-(3-Nitroamidino)-N2-[(1,1-dimethylethoxy)carbonyl]-L-lysine
EINECS	Contact for details

Quality Control

Our 2-(tert-Butoxycarbonylamino)-6-(3-Nitroguanidino)Hexanoic Acid is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for research and cGMP applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity (typically >97% by HPLC), and impurity profiles. We adhere to relevant ICH guidelines for stability and impurity characterization to support your regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.