Description

Cbz-R-3-Aminoisobutyric Acid CAS NO 132696-46-9 is a protected amino acid derivative, specifically the carboxybenzyl (Cbz) form of (R)-3-aminoisobutyric acid. This compound is a crucial chiral building block in the synthesis of complex peptides and peptidomimetics, offering a versatile handle for solid-phase and solution-phase chemistry. It is primarily utilized by pharmaceutical R&D departments and fine chemical manufacturers for developing active pharmaceutical ingredients (APIs), prodrugs, and novel bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of peptide-based drugs and protease inhibitors.
• Peptide Chemistry: Used in solid-phase peptide synthesis (SPPS) and solution-phase coupling to introduce the (R)-3-aminoisobutyric acid residue.
• Prodrug Development: Serves as a protected precursor for amino acid-based prodrugs designed to enhance drug solubility and bioavailability.
• Bioconjugation: Employed in the preparation of labeled peptides and protein conjugates for research and diagnostic applications.
• Chemical Biology Research: Utilized as a tool compound to study enzyme-substrate interactions and to create custom amino acid libraries.
• Asymmetric Synthesis: Acts as a chiral auxiliary or starting material in the preparation of non-natural amino acids and other enantiomerically pure compounds.

Basic Information

Product Name	Cbz-R-3-Aminoisobutyric Acid
CAS No.	132696-46-9
Molecular Formula	C12H15NO4
Molecular Weight	237.25 g/mol
Synonyms	(R)-3-((Benzyloxycarbonyl)amino)isobutyric acid; (R)-2-((Benzyloxycarbonyl)amino)-2-methylpropanoic acid; N-Cbz-(R)-3-Aminoisobutyric Acid; N-[(Benzyloxy)carbonyl]-D-3-aminoisobutyric acid; N-Carbobenzoxy-D-3-aminoisobutyric acid; Z-D-3-Aib-OH; Z-(R)-3-Aminoisobutyric Acid
EINECS	Contact for details

Quality Control

Our Cbz-R-3-Aminoisobutyric Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure high chemical purity, correct stereochemistry, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, reporting key parameters such as assay, enantiomeric excess, and impurity profiles. We support cGMP compliance for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant in the container.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.