Description

(1S,4S)-tert-Butyl 5-Benzyl-2,5-Diazabicyclo[2.2.1]Heptane-2-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a constrained diazabicyclic scaffold. This compound is a critical chiral building block for the synthesis of complex bioactive molecules, offering significant value in the development of targeted therapeutics. It is primarily required by research institutions and pharmaceutical companies engaged in medicinal chemistry, particularly for the development of central nervous system (CNS) agents and other specialized drug candidates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of novel active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a constrained scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Ligand Synthesis: Serves as a precursor for the development of sophisticated ligands in catalysis and chemical biology.
• Asymmetric Synthesis: Utilized in the construction of complex, enantiomerically pure molecules due to its defined stereochemistry.
• Chemical Reference Standard: Employed as a high-purity analytical standard for quality control and method development.

Basic Information

Product Name	(1S,4S)-tert-Butyl 5-Benzyl-2,5-Diazabicyclo[2.2.1]Heptane-2-Carboxylate
CAS No.	132666-68-3
Molecular Formula	C17H24N2O2
Molecular Weight	288.39 g/mol
Synonyms	tert-Butyl (1S,4S)-5-benzyl-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate; 2,5-Diazabicyclo[2.2.1]heptane-2-carboxylic acid, 5-(phenylmethyl)-, 1,1-dimethylethyl ester, (1S,4S)-; (1S,4S)-5-Benzyl-2-(tert-butoxycarbonyl)-2,5-diazabicyclo[2.2.1]heptane; (1S,4S)-N-Boc-5-benzyl-2,5-diazabicyclo[2.2.1]heptane; BOC-DBCO-Benzyl Amine Derivative
EINECS	Contact for details

Quality Control

Our (1S,4S)-tert-Butyl 5-Benzyl-2,5-Diazabicyclo[2.2.1]Heptane-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure identity, purity, and enantiomeric excess meet the highest standards for research and development. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.