Description

Bicyclo[1.1.1]pentane-1-carboxylic acid, 3-(1,1-dimethylethyl)- is a highly strained, rigid bicyclic carboxylic acid derivative that serves as a valuable and versatile building block in advanced organic synthesis. Its unique three-dimensional, paddlewheel-like structure is prized for its ability to impart significant steric and electronic effects, making it a critical component in the development of novel materials and bioactive compounds. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and material science industries seeking to explore new chemical space and optimize molecular properties.

Application

• Pharmaceutical Intermediate: A key synthon for creating drug candidates with improved metabolic stability, bioavailability, and target selectivity, particularly in medicinal chemistry programs.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, where its rigid core can enhance potency and environmental persistence.
• Material Science & Polymer Chemistry: Incorporated into monomers to produce polymers with unique mechanical properties, thermal stability, and low dielectric constants for advanced electronics.
• Ligand & Catalyst Development: Serves as a backbone for designing sterically demanding ligands used in asymmetric catalysis and transition metal complexes.
• Chemical Biology & Probe Design: Utilized as a bioisostere for phenyl or tert-butyl groups to modulate the physicochemical properties of molecular probes and imaging agents.
• Academic & Industrial R&D: A fundamental reagent for methodological studies in organic synthesis, exploring new C-H functionalization and cross-coupling reactions involving strained systems.

Basic Information

Product Name	Bicyclo[1.1.1]pentane-1-carboxylic acid, 3-(1,1-dimethylethyl)-
CAS No.	132663-73-1
Molecular Formula	C11H18O2
Molecular Weight	182.26 g/mol
Synonyms	3-tert-Butylbicyclo[1.1.1]pentane-1-carboxylic Acid; 3-(tert-Butyl)bicyclo[1.1.1]pentane-1-carboxylic Acid; 3-tert-Butyl-BCP-COOH; 3-(1,1-Dimethylethyl)bicyclo[1.1.1]pentane-1-carboxylic Acid; BCP-tBu-COOH; tert-Butyl Bicyclo[1.1.1]pentanecarboxylate Derivative; 1-Carboxy-3-tert-butylbicyclo[1.1.1]pentane
EINECS	Contact for details

Quality Control

Our production of Bicyclo[1.1.1]pentane-1-carboxylic acid, 3-(1,1-dimethylethyl)- adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for research and development applications. All materials are characterized and released against comprehensive specifications, including identity confirmation by spectroscopic methods and purity assessment by chromatographic techniques. A Certificate of Analysis (COA) detailing all critical quality attributes is provided with each shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.