Description

(2R,4S)-4-(Aminomethyl)-1-(tert-Butoxycarbonyl)Pyrrolidine-2-Carboxylic Acid CAS NO 132622-86-7 is a high-purity, chiral non-natural amino acid derivative featuring a pyrrolidine scaffold with orthogonal protecting groups. This compound is a critical pharmaceutical intermediate and building block for the synthesis of complex bioactive molecules, offering precise stereochemical control. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and biotechnology sectors for developing new therapeutic agents, including protease inhibitors and other peptidomimetics.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for protease inhibitors and other peptidomimetic drugs.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis to introduce constrained proline-like structures with a free amino group for further coupling.
• Medicinal Chemistry Research: Serves as a versatile scaffold in drug discovery programs for creating compound libraries and exploring structure-activity relationships (SAR).
• Bioconjugation: The primary amine functionality allows for conjugation to other molecules, such as fluorescent dyes or polymers, for creating targeted probes or drug delivery systems.
• Catalyst Ligand Synthesis: Can be utilized in the preparation of chiral ligands for asymmetric catalysis.
• Chemical Biology Probes: Employed in the development of enzyme inhibitors and activity-based probes for studying biological pathways.

Basic Information

Product Name	(2R,4S)-4-(Aminomethyl)-1-(tert-Butoxycarbonyl)Pyrrolidine-2-Carboxylic Acid
CAS No.	132622-86-7
Molecular Formula	C12H22N2O4
Molecular Weight	258.32 g/mol
Synonyms	Boc-4-(Aminomethyl)-D-proline; (2R,4S)-1-Boc-4-(aminomethyl)pyrrolidine-2-carboxylic acid; (2R,4S)-1-(tert-Butoxycarbonyl)-4-(aminomethyl)pyrrolidine-2-carboxylic acid; 4-(Aminomethyl)-1-Boc-D-proline; Boc-D-4-(Aminomethyl)proline; (2R,4S)-4-(Aminomethyl)-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid; (2R,4S)-1-(tert-Butoxycarbonyl)-4-(aminomethyl)-2-pyrrolidinecarboxylic acid
EINECS	Contact for details

Quality Control

Our (2R,4S)-4-(Aminomethyl)-1-(tert-Butoxycarbonyl)Pyrrolidine-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and enantiomeric purity suitable for advanced research and GMP-grade synthesis. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider storing under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.