Description

(2R,4R)-1-(tert-Butoxycarbonyl)-4-Cyanopyrrolidine-2-Carboxylic Acid is a high-purity, chiral non-natural amino acid derivative that serves as a critical building block in modern organic synthesis. Its value lies in its role as a key intermediate for constructing complex molecules with defined stereochemistry, essential for developing bioactive compounds. This product is primarily needed by pharmaceutical research and development organizations and fine chemical manufacturers engaged in producing peptide mimetics, protease inhibitors, and other advanced therapeutic agents.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon in the synthesis of novel drug candidates, particularly protease inhibitors and other enzyme-targeted therapies.
• Peptidomimetics Construction: Used to introduce constrained pyrrolidine scaffolds into peptide backbones to enhance metabolic stability and biological activity.
• Asymmetric Synthesis: Serves as a starting material or auxiliary in catalytic asymmetric reactions to create enantiomerically pure compounds.
• Chemical Biology & Proteomics: Employed in the design and synthesis of activity-based probes and labeled compounds for studying enzyme function.
• Agrochemical Research: Potential intermediate in the development of chiral active ingredients with specific modes of action.
• Academic & Contract Research: Used in universities and CROs for methodological development and exploring new chemical spaces in medicinal chemistry.

Basic Information

Product Name	(2R,4R)-1-(tert-Butoxycarbonyl)-4-Cyanopyrrolidine-2-Carboxylic Acid
CAS No.	132622-85-6
Molecular Formula	C11H16N2O4
Molecular Weight	240.26 g/mol
Synonyms	(2R,4R)-1-Boc-4-cyanopyrrolidine-2-carboxylic acid; (2R,4R)-1-[(tert-Butoxy)carbonyl]-4-cyanopyrrolidine-2-carboxylic acid; (2R,4R)-4-Cyano-1-[(2-methyl-2-propanyl)oxycarbonyl]-2-pyrrolidinecarboxylic acid; Boc-(2R,4R)-4-CN-Pro-OH; (2R,4R)-1-(Boc)-4-cyanopyrrolidine-2-carboxylic acid; tert-Butyl (2R,4R)-4-cyano-2-(carboxy)pyrrolidine-1-carboxylate; (2R,4R)-1-N-Boc-4-cyanopyrrolidine-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our production of (2R,4R)-1-(tert-Butoxycarbonyl)-4-Cyanopyrrolidine-2-Carboxylic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and high chemical purity. Each lot is fully characterized and tested using advanced analytical techniques including HPLC, chiral HPLC, NMR, and mass spectrometry to confirm identity, enantiomeric excess, and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.