Description

(2S,4R)-1-Boc-4-Amino-Pyrrolidine-2-Carboxylic Acid is a high-purity, non-natural amino acid derivative featuring a Boc-protected amine and a free carboxylic acid group, making it a versatile chiral building block. This compound is critical for the synthesis of complex molecules where precise stereochemistry and orthogonal protecting group strategies are required. It is primarily utilized by pharmaceutical R&D and process chemistry teams for the development of peptide-based therapeutics, protease inhibitors, and other bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for protease inhibitors and peptidomimetics.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis (SPPS) to introduce constrained proline-like structures with defined stereochemistry.
• Chemical Biology & Drug Discovery: Serves as a building block for creating focused libraries and molecular probes to study protein-ligand interactions.
• Asymmetric Synthesis: Employed as a chiral auxiliary or precursor in catalytic asymmetric transformations to construct complex molecular architectures.
• Bioconjugation: The free carboxylic acid group enables conjugation to other molecules, peptides, or surfaces for various research applications.

Basic Information

Product Name	(2S,4R)-1-Boc-4-Amino-Pyrrolidine-2-Carboxylic Acid
CAS No.	132622-69-6
Molecular Formula	C10H18N2O4
Molecular Weight	230.26 g/mol
Synonyms	1-Boc-4-amino-(2S,4R)-proline; (2S,4R)-4-Amino-1-[(tert-butoxy)carbonyl]pyrrolidine-2-carboxylic acid; Boc-4-Amino-D-proline; tert-Butyl (2S,4R)-4-amino-2-carboxypyrrolidine-1-carboxylate; (2S,4R)-1-(tert-Butoxycarbonyl)-4-aminopyrrolidine-2-carboxylic acid; Boc-Amp(2S,4R)-OH; 4-Amino-1-Boc-(2S,4R)-proline
EINECS	Contact for details

Quality Control

Our (2S,4R)-1-Boc-4-Amino-Pyrrolidine-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% de
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.