Description

5-Heptenoic Acid, 7-[3-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]-5-Oxo-1-Cyclopenten-1-Yl]-, Methyl Ester, (Z)- (9Ci) is a high-purity, advanced pharmaceutical intermediate featuring a complex molecular architecture with a silyl-protected hydroxyl group and a cyclopentenone moiety. This compound matters as a critical building block in the synthesis of complex bioactive molecules, offering precise stereochemistry and functional group compatibility for multi-step organic transformations. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, particularly in the fields of oncology and inflammation.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of prostaglandin analogs and other potent bioactive molecules.
• Organic Synthesis Building Block: Utilized in complex organic reactions, including cross-coupling and cycloaddition, due to its reactive olefin and ketone functionalities.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies in drug discovery programs targeting enzyme inhibition.
• Process Chemistry Development: Used in the scale-up and optimization of synthetic routes for active pharmaceutical ingredients (APIs) under GMP-like conditions.
• Academic Research: Employed in university and institutional labs for methodological studies in asymmetric synthesis and protecting group chemistry.

Basic Information

Product Name	5-Heptenoic Acid, 7-[3-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]-5-Oxo-1-Cyclopenten-1-Yl]-, Methyl Ester, (Z)- (9Ci)
CAS No.	132619-70-6
Molecular Formula	C19H32O4Si
Molecular Weight	352.54 g/mol
Synonyms	(Z)-Methyl 7-(3-((tert-Butyldimethylsilyl)oxy)-5-oxocyclopent-1-en-1-yl)hept-5-enoate; Methyl (Z)-7-[3-[(tert-Butyldimethylsilyl)oxy]-5-oxo-1-cyclopenten-1-yl]-5-heptenoate; TBDMS-protected Prostaglandin Intermediate; tert-Butyldimethylsilyl Prostaglandin Synthon; 132619-70-6; (Z)-Isomer of Methyl 7-(3-(tert-Butyldimethylsiloxy)-5-oxocyclopenten-1-yl)hept-5-enoate
EINECS	Contact for details

Quality Control

Our 5-Heptenoic Acid, 7-[3-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]-5-Oxo-1-Cyclopenten-1-Yl]-, Methyl Ester, (Z)- (9Ci) is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral HPLC and NMR spectroscopy, to ensure high chemical and isomeric purity suitable for sensitive pharmaceutical applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for each lot to ensure traceability and compliance with your internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. Keep away from strong acids and incompatible organic solvents. For long-term storage, consider inert gas purging to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Isomeric Purity (Z-Isomer, HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.