Description

Boc-(R)-2-(Aminomethyl)-4-Methylpentanoic Acid is a high-purity, chiral amino acid derivative protected with a tert-butoxycarbonyl (Boc) group. This compound serves as a critical, enantiomerically pure building block for the synthesis of complex peptides and peptidomimetics, enabling precise control over stereochemistry in advanced pharmaceutical research. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology sectors for drug discovery and development programs. The CAS number for this material is 132605-96-0.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of protease inhibitors and other therapeutic peptides.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to introduce a protected, branched-chain amino acid residue with a defined (R)-configuration.
• Peptidomimetic Design: Essential for creating non-peptide compounds that mimic the structure and function of natural peptides, improving metabolic stability and bioavailability.
• Chemical Biology Probes: Employed in the construction of labeled or modified peptides for studying protein-protein interactions and enzyme mechanisms.
• Asymmetric Synthesis: Serves as a starting material or chiral auxiliary in the asymmetric synthesis of more complex, biologically active molecules.
• Academic & Institutional Research: Used in university and research institute laboratories for fundamental studies in organic chemistry and medicinal chemistry.

Basic Information

Product Name	Boc-(R)-2-(Aminomethyl)-4-Methylpentanoic Acid
CAS No.	132605-96-0
Molecular Formula	C12H23NO4
Molecular Weight	245.32 g/mol
Synonyms	(R)-2-((tert-Butoxycarbonyl)aminomethyl)-4-methylpentanoic acid; (R)-N-Boc-2-(Aminomethyl)-4-methylpentanoic Acid; Boc-D-Homoleucine; Boc-D-HomoLeu-OH; (R)-2-((Boc-amino)methyl)-4-methylpentanoic acid; N-[(1,1-Dimethylethoxy)carbonyl]-D-homoleucine; D-Homoleucine, N-[(1,1-dimethylethoxy)carbonyl]-
EINECS	Contact for details

Quality Control

Our Boc-(R)-2-(Aminomethyl)-4-Methylpentanoic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric purity and standard pharmacopeial identification tests, to ensure it meets the high standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) providing batch-specific data for identity, purity, and chiral purity is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.