Description

4-(Trifluoromethyl)-1,2-Diazine is a specialized heterocyclic building block containing a trifluoromethyl-substituted diazine core. This compound matters for its role as a key intermediate in the synthesis of advanced materials and active pharmaceutical ingredients (APIs), where the introduction of the trifluoromethyl group can significantly alter electronic properties, lipophilicity, and metabolic stability. It is needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel fluorinated compounds.

Application

• Pharmaceutical Intermediate: A crucial building block for synthesizing novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the CF3 group enhances biological activity and environmental persistence.
• Material Science Research: Serves as a precursor for fluorinated polymers, liquid crystals, and electronic materials that require specific dielectric properties and chemical resistance.
• Organic Synthesis & Catalysis: Employed as a reagent in cross-coupling reactions and as a ligand precursor in organometallic chemistry to develop new catalytic systems.
• Fluorine Chemistry Studies: A valuable substrate for investigating the reactivity and incorporation of trifluoromethyl groups into complex molecular architectures.

Basic Information

Product Name	4-(Trifluoromethyl)-1,2-Diazine
CAS No.	132537-44-1
Molecular Formula	C5H3F3N2
Molecular Weight	148.09 g/mol
Synonyms	4-(Trifluoromethyl)pyridazine; 4-(Trifluoromethyl)-1,2-diazabenzene; 4-Trifluoromethylpyridazine; Pyridazine, 4-(trifluoromethyl)-; 1,2-Diazine, 4-(trifluoromethyl)-; 4-CF3-Pyridazine; α,α,α-Trifluoro-p-diazine
EINECS	Contact for details

Quality Control

Our 4-(Trifluoromethyl)-1,2-Diazine is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality systems support development and cGMP manufacturing requirements for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.