Description

3-Methoxy-α-Methyl-4-(2-Thiazolyl)Benzeneacetic Acid is a high-purity, non-steroidal anti-inflammatory drug (NSAID) intermediate of significant commercial importance. Its value lies in its role as a critical building block for the synthesis of more complex active pharmaceutical ingredients (APIs), particularly in the development of COX-2 inhibitors. This compound is essential for pharmaceutical R&D laboratories and manufacturers engaged in producing advanced analgesic and anti-inflammatory medications.

Application

• Pharmaceutical Intermediate: Primary use as a key synthetic precursor in the manufacture of novel NSAIDs and COX-2 selective inhibitors.
• Active Pharmaceutical Ingredient (API) Development: Serves as a core scaffold in medicinal chemistry for designing new anti-inflammatory and analgesic drug candidates.
• Research & Development: Utilized in academic and industrial research settings for pharmacological studies and structure-activity relationship (SAR) optimization.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and impurity profiling of related APIs.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing specialized fine chemicals.

Basic Information

Product Name	3-Methoxy-α-Methyl-4-(2-Thiazolyl)Benzeneacetic Acid
CAS No.	132483-57-9
Molecular Formula	C₁₄H₁₃NO₃S
Molecular Weight	275.32 g/mol
Synonyms	2-[4-(1,3-Thiazol-2-yl)-2-methoxyphenyl]propanoic Acid; α-Methyl-4-(2-thiazolyl)-3-methoxybenzeneacetic Acid; 3-Methoxy-α-methyl-4-(thiazol-2-yl)benzeneacetic Acid; 4-(2-Thiazolyl)-3-methoxyphenylacetic Acid, α-Methyl-; L-745,337 Intermediate; COX-2 Inhibitor Intermediate; 2-(4-(Thiazol-2-yl)-2-methoxyphenyl)propanoic Acid
EINECS	Contact for details

Quality Control

Our production of 3-Methoxy-α-Methyl-4-(2-Thiazolyl)Benzeneacetic Acid adheres to stringent quality management protocols. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the exacting standards required for pharmaceutical synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting critical parameters such as assay, related substances, and residual solvents. We support compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed to prevent absorption of atmospheric moisture, which can affect stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.