Description

α-Methyl-4-[4-(Methylcarbamoyl)-2-Thiazolyl]Benzeneacetic Acid is a high-purity, non-steroidal anti-inflammatory drug (NSAID) intermediate with significant pharmacological relevance. Its core value lies in its role as a key synthetic precursor for the development of potent and selective COX-2 inhibitors, which are crucial for advanced analgesic and anti-inflammatory therapies. This compound is essential for pharmaceutical R&D laboratories and manufacturers engaged in the synthesis of next-generation therapeutic agents targeting pain and inflammation management.

Application

• Pharmaceutical Intermediate: Primary building block in the synthesis of novel COX-2 inhibitor drugs (e.g., analogs of Celecoxib).
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies to develop new anti-inflammatory agents.
• Active Pharmaceutical Ingredient (API) Synthesis: A critical precursor in multi-step synthetic routes for producing non-steroidal anti-inflammatory drug candidates.
• Biochemical Research: Serves as a tool compound for studying cyclooxygenase enzyme inhibition mechanisms and pathways.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	α-Methyl-4-[4-(Methylcarbamoyl)-2-Thiazolyl]Benzeneacetic Acid
CAS No.	132483-51-3
Molecular Formula	C15H16N2O3S
Molecular Weight	304.36 g/mol
Synonyms	2-[4-(4-Methylcarbamoyl-2-thiazolyl)phenyl]propionic Acid; 4-[4-(Methylaminocarbonyl)-2-thiazolyl]-α-methylbenzeneacetic Acid; SC-57666; Celecoxib Intermediate; COX-2 Inhibitor Intermediate; Thiazole Acetic Acid Derivative; α-Methyl-4-(4-(methylcarbamoyl)thiazol-2-yl)benzeneacetic Acid
EINECS	Contact for details

Quality Control

Our α-Methyl-4-[4-(Methylcarbamoyl)-2-Thiazolyl]Benzeneacetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure compliance with stringent pharmaceutical intermediate standards. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability and batch-to-batch consistency for your critical R&D and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.