Description

α-Methyl-4-(2-thiazolyl)-3-(trifluoromethyl)benzeneacetic acid is a high-purity, non-steroidal anti-inflammatory drug (NSAID) intermediate with significant synthetic utility. This compound matters for its role as a key building block in the production of advanced pharmaceutical actives, offering a critical trifluoromethyl-substituted aromatic scaffold. It is primarily needed by research institutions and manufacturers in the pharmaceutical and fine chemical industries engaged in the development and synthesis of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of selective COX-2 inhibitor drugs and other non-steroidal anti-inflammatory agents (NSAIDs).
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a core building block for constructing complex molecules with anti-inflammatory and analgesic properties.
• Medicinal Chemistry Research: Used in R&D for structure-activity relationship (SAR) studies and the discovery of new chemical entities targeting inflammation and pain pathways.
• Fine Chemical Production: Employed in custom synthesis and contract manufacturing for producing high-value, fluorinated specialty chemicals.
• Reference Standard: Supplied as an analytical standard for quality control and method development in pharmaceutical laboratories.

Basic Information

Product Name	α-Methyl-4-(2-Thiazolyl)-3-(Trifluoromethyl)Benzeneacetic Acid
CAS No.	132483-39-7
Molecular Formula	C₁₄H₁₀F₃NO₂S
Molecular Weight	313.30 g/mol
Synonyms	2-[4-(1,3-Thiazol-2-yl)-3-(trifluoromethyl)phenyl]propanoic acid; α-Methyl-4-(2-thiazolyl)-3-(trifluoromethyl)benzeneacetic acid; 4-(2-Thiazolyl)-α-methyl-3-(trifluoromethyl)benzeneacetic Acid; Valdecoxib Intermediate; SC-65872 (Intermediate); COX-2 Inhibitor Intermediate; 2-(4-(Thiazol-2-yl)-3-(trifluoromethyl)phenyl)propionic acid
EINECS	Contact for details

Quality Control

Our α-Methyl-4-(2-thiazolyl)-3-(trifluoromethyl)benzeneacetic acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical intermediate applications. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.