Description

3-Chloro-α-Methyl-4-(2-Thiazolyl)Benzeneacetic Acid is a high-purity, non-steroidal anti-inflammatory drug (NSAID) intermediate with significant pharmacological relevance. This compound is valued for its role as a key synthetic precursor in the development of novel therapeutic agents targeting inflammation and pain. It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the production of advanced active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of proprietary NSAID candidates and COX-2 inhibitor analogs.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization programs.
• Fine Chemical Synthesis: Serves as a versatile synthon for constructing complex heterocyclic molecules with potential biological activity.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP-scale API production.
• Academic Research: Utilized in university and institutional labs for pharmacological and biochemical studies.

Basic Information

Product Name	3-Chloro-α-Methyl-4-(2-Thiazolyl)Benzeneacetic Acid
CAS No.	132483-33-1
Molecular Formula	C₁₃H₁₀ClNO₂S
Molecular Weight	279.74 g/mol
Synonyms	3-Chloro-α-methyl-4-(2-thiazolyl)benzeneacetic acid; 2-[3-Chloro-4-(1,3-thiazol-2-yl)phenyl]propanoic acid; 3-Chloro-4-(2-thiazolyl)-α-methylbenzeneacetic acid; 2-(3-Chloro-4-(thiazol-2-yl)phenyl)propionic acid; α-Methyl-3-chloro-4-(2-thiazolyl)benzeneacetic acid; 132483-33-1; Lornoxicam intermediate; Propanoic acid, 2-[3-chloro-4-(2-thiazolyl)phenyl]-
EINECS	Contact for details

Quality Control

Our 3-Chloro-α-Methyl-4-(2-Thiazolyl)Benzeneacetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with ICH guidelines, supporting its use in regulated pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.