Description

3-Chloro-4-(Trifluoromethyl)Benzene-1-Sulfonyl Chloride is a high-value, multi-functional aromatic sulfonyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its core value lies in its dual reactive sites—the sulfonyl chloride and the chloro-trifluoromethyl substituted aromatic ring—which enable precise molecular construction for complex target molecules. This compound is essential for R&D chemists and process engineers in the pharmaceutical and agrochemical industries who require reliable, high-purity intermediates for developing active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of sulfonamide-based drugs, including enzyme inhibitors and receptor antagonists.
• Agrochemical Synthesis: Building block for creating novel herbicides, fungicides, and insecticides with enhanced activity and selectivity.
• Material Science: Used in the production of specialty polymers, liquid crystals, and advanced electronic materials.
• Dye and Pigment Manufacturing: Intermediate for synthesizing complex organic dyes and colorants.
• Cross-coupling Reactions: Serves as an electrophile in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions.
• Chemical Research & Development: A versatile reagent for exploring new reaction pathways and creating compound libraries in medicinal chemistry.

Basic Information

Product Name	3-Chloro-4-(Trifluoromethyl)Benzene-1-Sulfonyl Chloride
CAS No.	132481-85-7
Molecular Formula	C7H3Cl2F3O2S
Molecular Weight	278.06 g/mol
Synonyms	3-Chloro-4-(trifluoromethyl)benzenesulfonyl chloride; 2-Chloro-α,α,α-trifluoro-p-toluenesulfonyl chloride; 4-Chloro-3-(trifluoromethyl)benzenesulfonyl chloride; 3-Chloro-4-trifluoromethylbenzenesulfonyl chloride; 1-Chloro-2-((trifluoromethyl)sulfonyl)benzene (incorrect but common misnomer); CTFBSC; Contact for additional trade names and abbreviations.
EINECS	Contact for details

Quality Control

Every batch of 3-Chloro-4-(Trifluoromethyl)Benzene-1-Sulfonyl Chloride is manufactured and tested under a strict quality management system. We ensure compliance with relevant industry standards for fine chemical intermediates. Comprehensive analytical testing, including HPLC, GC, and NMR, is performed to verify identity, purity, and impurity profiles. A detailed Certificate of Analysis (COA) is provided with each shipment to guarantee batch-to-batch consistency and support your regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis. Keep away from strong bases, oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.