Description

S(-)-Bzm Hydrochloride is the hydrochloride salt of the S-enantiomer of a key benzomorphan derivative. This chiral building block is critical for research and development in medicinal chemistry, where stereochemical purity directly impacts biological activity and pharmacological outcomes. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of novel therapeutic agents, particularly in the areas of central nervous system (CNS) targeting and analgesic research.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to investigate the role of stereochemistry on receptor binding and efficacy.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in analytical laboratories.
• Preclinical Development: Employed in the synthesis of candidate compounds for pharmacological screening and toxicology studies.
• Asymmetric Synthesis: Utilized as a starting material or intermediate in enantioselective synthetic routes.
• Academic Research: Used in university and institutional labs for studies in organic synthesis, pharmacology, and neurochemistry.

Basic Information

Product Name	S(-)-Bzm Hydrochloride
CAS No.	132448-73-8
Molecular Formula	C17H25NO2 • HCl
Molecular Weight	311.85 g/mol (free base: 275.39 g/mol)
Synonyms	(-)-Bzm HCl; S-(-)-Benzomorphan Hydrochloride; (S)-Bzm•HCl; 1,2,3,4,5,6-Hexahydro-8-hydroxy-3,6,11-trimethyl-2,6-methano-3-benzazocin-8-ol Hydrochloride, (2S,6R,11S)-isomer; (-)-N-Methylbenzomorphan Hydrochloride; S(-)-MR 2034 HCl; Potential opioid receptor ligand intermediate.
EINECS	Contact for details

Quality Control

Our S(-)-Bzm Hydrochloride is produced under controlled conditions to ensure high chiral purity and chemical consistency, meeting the stringent requirements of research and development applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles. We adhere to a rigorous quality management system, and specifications can be tailored to meet specific project needs, including compliance with cGMP standards for advanced non-clinical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Excess (Chiral HPLC)	≥99.0%
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.