Description

n-Boc-N'-Trityl-L-Glutamine is a high-purity, protected amino acid derivative essential for advanced peptide synthesis. This compound is critical for researchers and manufacturers who require precise control over side-chain reactivity during the construction of complex peptide sequences. It is primarily utilized in the pharmaceutical, biotechnology, and academic research sectors for the development of novel therapeutic peptides and peptidomimetics.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key building block for introducing glutamine residues with orthogonal protection of the side chain amine and α-amino groups.
• Solution-Phase Peptide Synthesis: Used in the synthesis of peptide fragments and complex natural products where selective deprotection is required.
• Pharmaceutical Intermediate: Serves as a critical raw material in the research and production of peptide-based active pharmaceutical ingredients (APIs).
• Bioconjugation Chemistry: Employed in the site-specific modification of peptides and proteins for drug delivery and diagnostic applications.
• Combinatorial Chemistry Libraries: Used to generate diverse arrays of glutamine-containing compounds for high-throughput screening in drug discovery.
• Academic & Institutional Research: A fundamental reagent for studying peptide structure, function, and for the chemical synthesis of bioactive peptides.

Basic Information

Item	Detail
Product Name	n-Boc-N'-Trityl-L-Glutamine
CAS No.	132388-69-3
Molecular Formula	C29H32N2O5
Molecular Weight	488.58 g/mol
Synonyms	(2S)-5-[(Triphenylmethyl)amino]-2-{[(2-methylpropan-2-yl)oxy]carbonylamino}-5-oxopentanoic acid; Nα-Boc-Nω-trityl-L-glutamine; Boc-Gln(Trt)-OH; N-tert-Butoxycarbonyl-N'-trityl-L-glutamine; L-Glutamine, N-[(1,1-dimethylethoxy)carbonyl]-N'-(triphenylmethyl)-; Boc-L-Glutamine(Trt)-OH; N-Boc-N'-tritylglutamine
EINECS	Contact for details

Quality Control

Our n-Boc-N'-Trityl-L-Glutamine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation (IR, NMR) to ensure it meets the exacting standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation [α]D20	-15.0° to -18.0° (c=1 in DMF)
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.