Description

Boc-n-β-Trityl-L-Asparagine is a protected derivative of the amino acid L-asparagine, featuring both tert-butoxycarbonyl (Boc) and trityl protecting groups. This compound is critically important as a high-purity, specialty building block for the synthesis of complex peptides and peptidomimetics, where precise control over side-chain reactivity is required. It is primarily needed by research institutions and pharmaceutical companies engaged in advanced peptide chemistry, drug discovery, and the development of therapeutic agents.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected intermediate for the controlled incorporation of L-asparagine into peptide chains, preventing unwanted side reactions.
• Solution-Phase Peptide Chemistry: Used in the synthesis of complex peptides, glycopeptides, or peptide conjugates in solution, offering orthogonal protection strategies.
• Pharmaceutical Research & Development: Serves as a crucial building block in the discovery and development of novel peptide-based drugs, hormones, and diagnostic agents.
• Bioconjugation and Probe Synthesis: Facilitates the site-specific modification of peptides for creating labeled probes, imaging agents, or antibody-drug conjugates (ADCs).
• Academic & Industrial Research: Employed in chemical biology studies to investigate protein-protein interactions, enzyme substrates, and structure-activity relationships (SAR).
• Custom Synthesis Services: Supplied to contract research and manufacturing organizations (CROs/CMOs) for client-specific custom synthesis projects.

Basic Information

Product Name	Boc-n-β-Trityl-L-Asparagine
CAS No.	132388-68-2
Molecular Formula	C32H32N2O5
Molecular Weight	524.61 g/mol
Synonyms	Nα-Boc-Nβ-trityl-L-asparagine; Boc-Asn(Trt)-OH; tert-Butyl N-[(2S)-1-[(triphenylmethyl)amino]-1-oxo-3-[(tert-butoxycarbonyl)amino]propan-2-yl]carbamate; N-[(1,1-Dimethylethoxy)carbonyl]-N-(triphenylmethyl)-L-asparagine; (S)-2-((tert-Butoxycarbonyl)amino)-3-((tritylamino)carbonyl)propanoic acid; Boc-L-Asn(Trt)-OH; L-Asparagine, N2-[(1,1-dimethylethoxy)carbonyl]-N4-(triphenylmethyl)-
EINECS	Contact for details

Quality Control

Our Boc-n-β-Trityl-L-Asparagine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for pharmaceutical research and peptide synthesis. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation [α]D20	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.