Description

N'-Trityl-L-Asparagine is a protected derivative of the amino acid L-asparagine, featuring a trityl (triphenylmethyl) group on the side-chain amide nitrogen. This compound is of critical importance in peptide synthesis and medicinal chemistry as a versatile building block, where it serves to protect the reactive amide functionality during complex coupling reactions. It is primarily needed by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers engaged in the development of novel peptides, peptidomimetics, and bioactive molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid derivative for the controlled assembly of peptide chains, preventing side reactions at the asparagine residue.
• Solution-Phase Peptide Synthesis: Used in classical peptide coupling methodologies to ensure high purity and yield of target sequences.
• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of peptide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Bioconjugation & Labeling: The protected amide allows for selective modification of peptides for creating fluorescent probes, biotinylated compounds, or drug conjugates.
• Research & Development: Essential for academic and industrial research exploring protein structure-function relationships, enzyme substrates, and receptor ligands.
• Production of Specialty Peptides: Enables the commercial-scale manufacturing of therapeutic peptides, diagnostic agents, and cosmetic peptides.

Basic Information

Product Name	N'-Trityl-L-Asparagine
CAS No.	132388-58-0
Molecular Formula	C25H24N2O3
Molecular Weight	400.47 g/mol
Synonyms	L-Asparagine, N-[(triphenylmethyl)]-; N(alpha)-Trityl-L-asparagine; N-Tritylasparagine; Trt-Asn-OH; Nδ-Trityl-L-asparagine; (2S)-2-amino-4-oxo-4-[(tritylamino)]butanoic acid; Fmoc-Asn(Trt)-OH (related derivative); Asparagine derivative with trityl protection
EINECS	Contact for details

Quality Control

Our N'-Trityl-L-Asparagine is produced under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding synthetic applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, and is supplied with a detailed Certificate of Analysis (COA). We adhere to cGMP principles where applicable to support our clients in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture uptake, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]	Contact for details
Chiral Purity (HPLC)	≥99.0%
Loss on Drying	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.