Description

(S)-N1-[(3-Dihydroxy-2-Phosphonylmethoxy)Propyl]-N4-Benzoyl-Cytosine is a high-purity, nucleoside-based intermediate of significant interest in advanced pharmaceutical research and development. This compound is valued for its role as a key building block in the synthesis of novel antiviral and anticancer nucleotide analogs. It is primarily sought by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the development of next-generation therapeutic agents. The precise stereochemistry and functional groups make it a critical precursor for targeted drug discovery programs.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of experimental antiviral and anticancer nucleotide prodrugs.
• Antiviral Research: Used in the development of nucleotide analogs targeting viral polymerases, with potential applications against a range of DNA and RNA viruses.
• Oncology Drug Discovery: Serves as a building block for creating cytostatic agents that interfere with DNA synthesis in rapidly dividing cells.
• Biochemical Research: Employed in studies of enzyme kinetics and mechanisms, particularly those involving nucleotide-metabolizing enzymes.
• Prodrug Development: Utilized to design masked phosphate derivatives (phosphonates) to improve the cellular uptake and bioavailability of active drug molecules.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method validation in pharmaceutical manufacturing.

Basic Information

Product Name	(S)-N1-[(3-Dihydroxy-2-Phosphonylmethoxy)Propyl]-N4-Benzoyl-Cytosine
CAS No.	132336-37-9
Molecular Formula	C16H20N3O8P
Molecular Weight	413.32 g/mol
Synonyms	(S)-HPMPC Bz; (S)-9-(3-Hydroxy-2-phosphonylmethoxypropyl)-N4-benzoylcytosine; (S)-N4-Benzoyl-1-[(3-hydroxy-2-phosphonylmethoxy)propyl]cytosine; (S)-N4-Benzoyl-HPMPC; Benzoyl Cidofovir Intermediate; (S)-1-[(3-Hydroxy-2-phosphonomethoxy)propyl]-N4-benzoylcytosine; (S)-N4-Benzoyl-1-[(3-hydroxy-2-(phosphonomethoxy)propyl]cytosine
EINECS	Contact for details

Quality Control

Our (S)-N1-[(3-Dihydroxy-2-Phosphonylmethoxy)Propyl]-N4-Benzoyl-Cytosine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis to confirm stereochemical integrity, and comprehensive identification tests. We provide full traceability and a detailed Certificate of Analysis (COA) with each shipment, ensuring compliance with the stringent requirements of pharmaceutical R&D and cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider desiccants or an inert atmosphere to maintain product stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (S-enantiomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.