Description

(S)-(+)-N,n-Dimethyl-3-(1-Naphthalenyloxy)-3-(2-Thienyl)Propanamine CAS NO 132335-46-7 is a high-purity chiral amine derivative featuring a naphthalene and thiophene moiety, serving as a critical advanced pharmaceutical intermediate. Its value lies in enabling the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs) with specific stereochemical requirements. This compound is essential for research and development chemists and process scale-up teams in the pharmaceutical and fine chemical industries, particularly for projects involving central nervous system (CNS) agents and other specialized therapeutics.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs).
• Chiral Catalyst/ Ligand Precursor: Used in the development of asymmetric synthesis catalysts and chiral auxiliaries.
• Neurological & CNS Drug Research: A vital intermediate in the R&D of compounds targeting serotonin and related neurotransmitter systems.
• Process Chemistry & Scale-up: Employed in route scouting, optimization, and pilot-scale manufacturing of complex drug molecules.
• Academic & Industrial Research: Serves as a standard or starting material for novel synthetic methodologies and structure-activity relationship (SAR) studies.
• Fine Chemical Synthesis: Used in the production of other specialty chemicals requiring its unique naphthalene-thiophene scaffold.

Basic Information

Product Name	(S)-(+)-N,n-Dimethyl-3-(1-Naphthalenyloxy)-3-(2-Thienyl)Propanamine
CAS No.	132335-46-7
Molecular Formula	C19H21NOS
Molecular Weight	311.44 g/mol
Synonyms	(S)-Duloxetine Intermediate; (S)-(+)-Duloxetine Impurity; (S)-N-Methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine; (S)-N,N-Dimethyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine; (S)-3-(1-Naphthalenyloxy)-3-(2-thienyl)-N,N-dimethyl-1-propanamine; LY248686 (S-enantiomer); (S)-N,N-Dimethyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine
EINECS	Contact for details

Quality Control

Our (S)-(+)-N,n-Dimethyl-3-(1-Naphthalenyloxy)-3-(2-Thienyl)Propanamine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) and standard purity assays, to ensure compliance with stringent specifications for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.