Description

(1S,2S,3S)-2,3-Bis(Benzoyloxymethyl)Cyclobutanol CAS NO 132294-17-8 is a high-purity, stereochemically defined cyclobutane derivative functionalized with benzoyl protecting groups. This compound serves as a critical chiral building block and advanced pharmaceutical intermediate, enabling the synthesis of complex molecules with precise three-dimensional architecture. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), especially within medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, particularly in antiviral, anticancer, and anti-inflammatory research.
• Asymmetric Synthesis: Utilized as a scaffold or precursor in stereoselective chemical reactions to construct complex, enantiomerically pure molecules.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization due to its rigid cyclobutane core and modifiable functional groups.
• Process Chemistry Development: Serves as a reference standard or starting material for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Academic Research: Used in organic chemistry laboratories for methodology development and studying cyclobutane chemistry and ester protection/deprotection strategies.
• Custom Synthesis: A foundational component for contract research and manufacturing organizations (CROs/CMOs) producing bespoke fine chemicals for client projects.

Basic Information

Product Name	(1S,2S,3S)-2,3-Bis(Benzoyloxymethyl)Cyclobutanol
CAS No.	132294-17-8
Molecular Formula	C21H22O5
Molecular Weight	354.40 g/mol
Synonyms	(1S,2S,3S)-2,3-Bis(benzoyloxymethyl)cyclobutan-1-ol; (1S,2S,3S)-2,3-Di(benzoyloxymethyl)cyclobutanol; cis,cis-2,3-Bis(benzoyloxymethyl)cyclobutanol; (1S,2S,3S)-Cyclobutane-1,2,3-triol, 2,3-bis(benzoyloxymethyl)-; (1S,2S,3S)-1,2,3-Cyclobutanetriol, 2,3-bis(benzoyloxymethyl)-; BOC-Protected Cyclobutanol Derivative; Chiral Cyclobutane Dibenzoate
EINECS	Contact for details

Quality Control

Our (1S,2S,3S)-2,3-Bis(Benzoyloxymethyl)Cyclobutanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting research and development standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically ≥97% by HPLC), enantiomeric excess, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.