Description

Endo-3-Boc-Aminotropane CAS NO 132234-69-6 is a protected amine derivative of tropane, serving as a crucial chiral building block and intermediate in advanced organic synthesis. Its primary value lies in enabling the controlled introduction of the aminotropane pharmacophore, a privileged scaffold in medicinal chemistry, while the Boc (tert-butoxycarbonyl) group provides orthogonal protection for selective deprotection strategies. This high-purity intermediate is essential for researchers and process chemists in the pharmaceutical and agrochemical industries developing novel active compounds, particularly for central nervous system (CNS) targets.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and development of novel pharmaceutical agents, especially those targeting neurological receptors.
• Medicinal Chemistry Research: Used as a versatile building block for constructing complex molecular libraries in drug discovery programs.
• Agrochemical Synthesis: Intermediate in the development of advanced crop protection agents with specific biological activity.
• Asymmetric Synthesis: Employed in stereoselective reactions to create enantiomerically pure compounds for high-value applications.
• Chemical Biology Probes: Utilized in the synthesis of labeled compounds or molecular probes for studying biological pathways and target engagement.
• Process Chemistry & Scale-up: Serves as a defined starting material for the optimization and commercial-scale production of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Endo-3-Boc-Aminotropane
CAS No.	132234-69-6
Molecular Formula	C₁₃H₂₃NO₂
Molecular Weight	225.33 g/mol
Synonyms	3-[(tert-Butoxycarbonyl)amino]-8-azabicyclo[3.2.1]octane; 8-Azabicyclo[3.2.1]octan-3-amine, N-BOC-; N-Boc-3-aminotropane; tert-Butyl 3-amino-8-azabicyclo[3.2.1]octane-8-carboxylate; Endo-N-Boc-3-Aminotropane; 3-Amino-8-azabicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our Endo-3-Boc-Aminotropane is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, typically meeting standards suitable for research and pharmaceutical development. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support our clients' regulatory needs with documentation traceability and can provide material suitable for cGMP (current Good Manufacturing Practice) applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.