Description

Exo-3-Boc-Aminotropane is a protected amine derivative of the tropane alkaloid class, serving as a critical chiral building block in advanced organic synthesis. Its primary value lies in providing a versatile, stereochemically defined scaffold for constructing complex molecules, particularly in pharmaceutical research and development. This high-purity intermediate is essential for medicinal chemists and process development scientists working on central nervous system (CNS) active compounds, novel receptor ligands, and other bioactive molecules.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the synthesis of novel tropane-based therapeutics and central nervous system (CNS) agents.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry Development: Serves as a starting material or advanced intermediate for developing scalable, GMP-compliant synthetic routes to active pharmaceutical ingredients (APIs).
• Neuroscience Research: Building block for creating labeled ligands or probes for studying neurotransmitter transporters and receptors.
• Asymmetric Synthesis: Employed as a chiral auxiliary or template in stereoselective synthesis to introduce complex molecular architectures.
• Academic & Contract Research: Fundamental research chemical for exploring new synthetic methodologies and novel chemical entities in university and CRO laboratories.

Basic Information

Product Name	Exo-3-Boc-Aminotropane
CAS No.	132234-68-5
Molecular Formula	C13H23NO2
Molecular Weight	225.33 g/mol
Synonyms	3-[(tert-Butoxycarbonyl)amino]-8-methyl-8-azabicyclo[3.2.1]octane; 3-[(tert-Butoxycarbonyl)amino]tropane; 3-Boc-Aminotropane; N-Boc-3-aminotropane; tert-Butyl 3-aminotropane-3-carboxylate; 8-Methyl-8-azabicyclo[3.2.1]octan-3-amine, N-Boc derivative; exo-N-Boc-3-aminotropane
EINECS	Contact for details

Quality Control

Our Exo-3-Boc-Aminotropane is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and KF titration for moisture content. A detailed Certificate of Analysis (COA) documenting all specifications is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept sealed in a dry environment and allowed to equilibrate to room temperature before opening to prevent moisture adsorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.