Description

(2R,3R)-2,3-Bis(Hydroxymethyl)Cyclobutanone is a high-value chiral synthon characterized by its unique cyclobutanone core flanked by hydroxymethyl groups in a specific stereochemical configuration. This compound matters as a versatile and stereochemically defined building block for the synthesis of complex pharmaceutical intermediates and fine chemicals. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and advanced material sectors for developing novel active ingredients and chiral ligands.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of novel drug candidates, particularly for antiviral, anticancer, and central nervous system (CNS) active compounds.
• Asymmetric Catalyst Ligand Synthesis: Used to construct sophisticated chiral ligands for transition metal catalysis, enabling highly enantioselective transformations.
• Agrochemical Research: Serves as a building block for developing new chiral pesticides and herbicides with improved efficacy and environmental profiles.
• Fine Chemical Synthesis: Employed in the multi-step synthesis of complex natural products, flavors, and fragrances requiring specific stereochemistry.
• Material Science Monomer: Potential use as a functional monomer for creating polymers with tailored mechanical and optical properties from its rigid cyclobutane structure.

Basic Information

Product Name	(2R,3R)-2,3-Bis(Hydroxymethyl)Cyclobutanone
CAS No.	132203-79-3
Molecular Formula	C7H12O3
Molecular Weight	144.17 g/mol
Synonyms	(2R,3R)-2,3-Di(hydroxymethyl)cyclobutanone; (2R,3R)-2,3-Bis(hydroxymethyl)cyclobutan-1-one; (2R-cis)-2,3-Bis(hydroxymethyl)cyclobutanone; cis-2,3-Bis(hydroxymethyl)cyclobutanone; (2R,3R)-Cyclobutanone-2,3-dimethanol; 1-Cyclobutanone-2,3-dimethanol, (2R,3R)-
EINECS	Contact for details

Quality Control

Our (2R,3R)-2,3-Bis(Hydroxymethyl)Cyclobutanone is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure compliance with exacting research and development standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.