Description

(2R,3S)-3-Phenylisoserine Hydrochloride is a high-purity, non-natural amino acid derivative and a key chiral building block in organic synthesis. Its precise stereochemistry makes it a critical intermediate for the production of complex pharmaceutical compounds, particularly taxane-based anticancer agents. This material is essential for research and development chemists, process chemists, and manufacturers in the pharmaceutical and fine chemical industries seeking reliable, high-quality chiral intermediates.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the semi-synthesis of paclitaxel (Taxol®) and docetaxel (Taxotere®).
• Organic Synthesis Building Block: Used in the asymmetric synthesis of complex molecules requiring the (2R,3S)-phenylisoserine moiety.
• Process Chemistry & Scale-Up: Serves as a starting material or intermediate in the development and optimization of API (Active Pharmaceutical Ingredient) manufacturing routes.
• Research & Development: Utilized in medicinal chemistry for the design and synthesis of novel bioactive compounds and analogs.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development and quality control in pharmaceutical production.

Basic Information

Item	Details
Product Name	(2R,3S)-3-Phenylisoserine Hydrochloride
CAS No.	132201-32-2
Molecular Formula	C9H12ClNO3
Molecular Weight	217.65 g/mol
Synonyms	(2R,3S)-3-Phenylisoserine HCl; (2R,3S)-3-Phenyl-D-serine Hydrochloride; (2R,3S)-β-Phenylserine Hydrochloride; (2R,3S)-3-Phenylisoserine Hydrochloride; (2R,3S)-3-Phenylserine Hydrochloride; (2R,3S)-3-Phenyl-L-allo-threonine Hydrochloride (deprecated); C13 Side Chain Intermediate for Paclitaxel
EINECS	Contact for details

Quality Control

Our (2R,3S)-3-Phenylisoserine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assay and impurity profiling by HPLC, to ensure it meets stringent specifications for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing identity, purity, and related substances are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% de
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.