Description

(2S)-5α-(6-Bromo-9H-Purine-9-Yl)Tetrahydro-2α-Furanmethanol CAS NO 132194-25-3 is a high-purity, advanced pharmaceutical intermediate characterized by its chiral furanmethanol structure attached to a brominated purine base. This compound matters for its critical role as a sophisticated building block in the synthesis of nucleoside analogs and other active pharmaceutical ingredients (APIs), where precise stereochemistry is paramount. Pharmaceutical research and development organizations, as well as fine chemical manufacturers, need this material to develop novel antiviral and anticancer therapeutics, leveraging its unique structure to impart specific biological activity.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel nucleoside analog drugs targeting viral infections and cancer.
• Antiviral Drug Research: Used in the R&D of purine-based antiviral agents, where the bromo-substitution offers a handle for further chemical modification.
• Oncology Drug Development: Serves as a precursor in creating potential chemotherapeutic agents that interfere with DNA/RNA synthesis in rapidly dividing cells.
• Biochemical Research: Employed in academic and industrial laboratories as a probe or substrate to study enzyme mechanisms involving purine metabolism.
• Process Chemistry & Scale-Up: Utilized by fine chemical manufacturers for the development and optimization of scalable synthetic routes to complex APIs.
• Custom Synthesis: Acts as a starting material for contract research organizations (CROs) and CDMOs performing bespoke synthesis for client projects.

Basic Information

Product Name	(2S)-5α-(6-Bromo-9H-Purine-9-Yl)Tetrahydro-2α-Furanmethanol
CAS No.	132194-25-3
Molecular Formula	C₁₀H₁₁BrN₄O₂
Molecular Weight	299.13 g/mol
Synonyms	(2S)-5α-(6-Bromo-9H-purin-9-yl)tetrahydro-2α-furanmethanol; (2S,5α)-5-(6-Bromo-9H-purin-9-yl)tetrahydrofuran-2-methanol; 6-Bromo-9-[(2S,5α)-5-(hydroxymethyl)tetrahydrofuran-2-yl]-9H-purine; 9-[(2S,5α)-5-(Hydroxymethyl)tetrahydrofuran-2-yl]-6-bromopurine; Brominated Purine Furanmethanol Derivative; (2S)-5α-(6-Bromopurin-9-yl)tetrahydro-2α-furanmethanol
EINECS	Contact for details

Quality Control

Our (2S)-5α-(6-Bromo-9H-Purine-9-Yl)Tetrahydro-2α-Furanmethanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.