Description

(2S)-5α-(6-Fluoro-9H-Purine-9-Yl)Tetrahydrofuran-2α-Methanol is a high-purity nucleoside analogue derivative, serving as a critical advanced pharmaceutical intermediate. Its value lies in enabling the synthesis of novel antiviral and anticancer agents, particularly within the field of modified nucleosides. This compound is essential for research institutions and pharmaceutical manufacturers focused on developing next-generation therapeutics, where precise stereochemistry and fluorination are required for biological activity.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of antiviral and anticancer nucleoside prodrugs.
• Antiviral Drug Research: Used in the development of novel compounds targeting viral polymerases and reverse transcriptases.
• Oncology Research: Serves as a precursor for potential chemotherapeutic agents that interfere with DNA/RNA synthesis in cancer cells.
• Biochemical Research: Utilized as a substrate or inhibitor in enzymatic studies to understand nucleotide metabolism.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the commercial manufacturing of active pharmaceutical ingredients (APIs).
• Reference Standard: Acts as a certified reference material (CRM) for quality control and analytical method development in pharmaceutical labs.

Basic Information

Product Name	(2S)-5α-(6-Fluoro-9H-Purine-9-Yl)Tetrahydrofuran-2α-Methanol
CAS No.	132194-24-2
Molecular Formula	C₁₀H₁₁FN₄O₂
Molecular Weight	238.22 g/mol
Synonyms	(2S)-5α-(6-Fluoro-9H-purin-9-yl)tetrahydrofuran-2α-methanol; 6-Fluoro-9-[(2S,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl]-9H-purine; 2'-Deoxy-2'-fluoro-β-D-arabinofuranosyladenine intermediate; 6-Fluoro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine precursor; 2-F-ara-A Intermediate; FAra-A Intermediate; 6-Fluoropurine arabinoside derivative; (2S,5S)-5-(Hydroxymethyl)-2-(6-fluoropurin-9-yl)tetrahydrofuran
EINECS	Contact for details

Quality Control

Our (2S)-5α-(6-Fluoro-9H-Purine-9-Yl)Tetrahydrofuran-2α-Methanol is manufactured under a strict quality management system. Every batch is subjected to comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are available upon request. We support development and commercial projects requiring material that meets stringent pharmaceutical intermediate standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.