Description

(2S)-5α-(2-Amino-6-Iodo-9H-Purine-9-Yl)Tetrahydrofuran-2α-Methanol is a high-purity nucleoside analog derivative, specifically designed for advanced pharmaceutical research and development. This compound is critical for its role as a key synthetic intermediate in the production of novel antiviral and anticancer therapeutics. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of modified nucleosides and oligonucleotides. The material's defined stereochemistry and functional groups make it an essential building block for probing biological mechanisms and developing targeted drug candidates.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of investigational antiviral and antineoplastic (anti-cancer) drugs.
• Nucleoside Chemistry Research: Used in academic and industrial R&D to study structure-activity relationships (SAR) and develop novel nucleoside analogs.
• Oligonucleotide Synthesis: Serves as a modified building block for creating labeled or therapeutic oligonucleotides for genetic research and therapy.
• Biochemical Probe Development: Employed in the creation of molecular probes to investigate enzyme mechanisms, particularly those involving purine metabolism.
• Medicinal Chemistry: Integral for lead optimization and scaffold modification in drug discovery programs targeting viral polymerases or cellular kinases.

Basic Information

Product Name	(2S)-5α-(2-Amino-6-Iodo-9H-Purine-9-Yl)Tetrahydrofuran-2α-Methanol
CAS No.	132194-23-1
Molecular Formula	C₁₀H₁₂IN₅O₂
Molecular Weight	361.14 g/mol
Synonyms	2-Amino-6-iodo-9-[(2S,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl]-9H-purine; 6-Iodo-2-aminopurine 2',3'-dideoxy-2',3'-didehydro-β-L-nucleoside derivative; 2-Amino-6-iodopurine carbocyclic nucleoside analog; L-2-Amino-6-iodopurine derivative; (2S,5S)-5-(Hydroxymethyl)-2-(2-amino-6-iodo-9H-purin-9-yl)tetrahydrofuran
EINECS	Contact for details

Quality Control

Our (2S)-5α-(2-Amino-6-Iodo-9H-Purine-9-Yl)Tetrahydrofuran-2α-Methanol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent control of residual solvents and impurities. Certificates of Analysis (COA) detailing all specifications and test results are provided to ensure traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and performance. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.