Description

(2S)-5α-(2-Amino-6-Bromo-9H-Purine-9-Yl)Tetrahydrofuran-2α-Methanol is a high-purity nucleoside analog derivative, a crucial advanced pharmaceutical intermediate (API) in modern synthetic chemistry. Its value lies in its role as a sophisticated building block for the development of novel antiviral and anticancer therapeutics, where precise stereochemistry and functional group integrity are paramount. This compound is essential for research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers focused on nucleoside-based drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex nucleoside analogs and prodrugs.
• Antiviral Drug Research: Serves as a critical precursor in the development of novel antiviral agents targeting viral polymerases.
• Oncology Therapeutics: Used in the research and development of purine-based chemotherapeutic agents and targeted cancer therapies.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies and molecular biology research involving purine metabolism.
• Process Chemistry & Scale-Up: Utilized by fine chemical manufacturers for the pilot-scale and commercial-scale production of active pharmaceutical ingredients (APIs).
• Custom Synthesis: Acts as a starting material for the custom synthesis of labeled compounds (e.g., deuterated, C13) for metabolic and pharmacokinetic studies.

Basic Information

Product Name	(2S)-5α-(2-Amino-6-Bromo-9H-Purine-9-Yl)Tetrahydrofuran-2α-Methanol
CAS No.	132194-22-0
Molecular Formula	C10H12BrN5O2
Molecular Weight	314.14 g/mol
Synonyms	2-Amino-6-bromo-9-[(2S,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl]-9H-purine; 6-Bromo-2-aminopurine riboside derivative; (2S,5S)-5-(Hydroxymethyl)-2-(2-amino-6-bromo-purin-9-yl)tetrahydrofuran; 2-Amino-6-bromopurine (2'S,5'S)-isomer; 9-[(2S,5S)-5-(Hydroxymethyl)tetrahydrofuran-2-yl]-2-amino-6-bromopurine; 6-Bromo-2-aminopurine nucleoside analog; Br2A-Purine riboside analog
EINECS	Contact for details

Quality Control

Every batch of (2S)-5α-(2-Amino-6-Bromo-9H-Purine-9-Yl)Tetrahydrofuran-2α-Methanol is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including chiral purity verification, to ensure compliance with exacting research and pharmaceutical intermediate standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity (HPLC), chiral purity, and impurity profiles is provided with each shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider desiccants or inert atmosphere packaging.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.