Description

Z-Arg(Z)2-Osu CAS NO 132160-73-7 is a protected arginine derivative, specifically the Nα,Nω-bis(benzyloxycarbonyl)-L-arginine N-hydroxysuccinimide ester. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled and efficient incorporation of arginine residues while preventing undesirable side reactions. It is essential for researchers and manufacturers developing therapeutic peptides, bioactive probes, and complex biomolecules in the pharmaceutical and biotechnology sectors.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key reagent for the controlled introduction of arginine into peptide chains.
• Therapeutic Peptide Development: Synthesis of peptide-based drug candidates, including antimicrobial peptides (AMPs) and hormone analogs.
• Bioconjugation and Labeling: Used to attach arginine-rich sequences or tags to proteins, antibodies, or other biomolecules.
• Research Grade Biochemicals: Production of custom peptides for academic and industrial research in cell signaling, enzymology, and drug discovery.
• GPCR Ligand Synthesis: Construction of peptides that target G-protein-coupled receptors for pharmacological studies.
• Vaccine Adjuvant Peptides: Incorporation into antigenic peptides where arginine residues can enhance immunogenicity.

Basic Information

Product Name	Z-Arg(Z)2-Osu
CAS No.	132160-73-7
Molecular Formula	C27H32N4O8
Molecular Weight	540.57 g/mol
Synonyms	Nα,Nω-Bis(benzyloxycarbonyl)-L-arginine N-hydroxysuccinimide ester; Nα,Nω-Bis-Cbz-L-arginine N-succinimidyl ester; Nα,Nω-Di-Z-L-arginine N-hydroxysuccinimide ester; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-guanidinopentanoic acid; Boc-Arg(Z)2-OH N-hydroxysuccinimide ester; Fmoc-Arg(Z)2-OSu; L-Arginine, N2,N5-bis[(phenylmethoxy)carbonyl]-, 1-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl) ester; Z-Arg(Z)2-OSu
EINECS	Contact for details

Quality Control

Our Z-Arg(Z)2-Osu is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis to ensure enantiomeric purity. Certificates of Analysis (COA) detailing all specifications are provided to guarantee consistency and suitability for sensitive applications like GMP-grade peptide synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, freezer environment. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.