Description

2-m-Hydroxy Paclitaxel is a key semi-synthetic derivative of the potent anticancer agent paclitaxel. This compound is of significant interest in pharmaceutical research and development due to its role as a crucial intermediate for synthesizing novel, potentially more effective or targeted taxane-based chemotherapeutics. It is primarily required by pharmaceutical companies, research institutions, and contract development and manufacturing organizations (CDMOs) engaged in advanced oncology drug discovery and production.

Application

• Pharmaceutical Intermediate: Critical starting material for the synthesis of next-generation paclitaxel analogs and prodrugs.
• Oncology Research: Used in biochemical and pharmacological studies to investigate structure-activity relationships (SAR) of taxane compounds.
• Drug Discovery: Serves as a building block in medicinal chemistry programs aimed at developing new anticancer agents with improved efficacy or reduced side effects.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development and impurity profiling.
• Process Chemistry: Utilized in the scale-up and optimization of synthetic routes for complex active pharmaceutical ingredients (APIs).

Basic Information

Product Name	2-m-Hydroxy Paclitaxel
CAS No.	132160-31-7
Molecular Formula	C47H51NO15
Molecular Weight	869.91 g/mol
Synonyms	2'-Methylpaclitaxel; 2'-Methyl Taxol; 2'-Methyl-7-epi-paclitaxel; 2'-Methyl-7-epitaxol; Paclitaxel, 2'-methyl-; 2'-O-Methylpaclitaxel; 2'-Methoxy Paclitaxel (common misnomer); 2'-Methyl Derivative of Paclitaxel
EINECS	Contact for details

Quality Control

Our 2-m-Hydroxy Paclitaxel is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) detailing all test results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed in a desiccated environment and away from light sources to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.