Description

(3R,4S,5S)-4-(tert-Butoxycarbonyl(Methyl)Amino)-3-Methoxy-5-Methylheptanoic Acid is a high-purity, non-natural amino acid derivative featuring a chiral backbone and a tert-butoxycarbonyl (Boc) protected amine. This compound is a critical chiral building block in the synthesis of complex pharmaceutical intermediates and active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and manufacturers in the pharmaceutical and biotechnology sectors for the development of novel therapeutics, particularly in peptide mimetics and enzyme inhibitor research.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Peptidomimetic Research: Used in the design and construction of peptide analogs and mimetics to enhance metabolic stability and bioavailability.
• Protease Inhibitor Development: Serves as a core structural component in the development of inhibitors for various proteolytic enzymes.
• Asymmetric Synthesis: Employed as a chiral auxiliary or building block in stereoselective organic synthesis to introduce specific stereocenters.
• Chemical Biology Probes: Utilized in the creation of labeled or modified compounds for studying biological pathways and target engagement.
• Process Chemistry & Scale-up: Suitable for use in process research and development (PR&D) and pilot-scale manufacturing of advanced intermediates.

Basic Information

Product Name	(3R,4S,5S)-4-(tert-Butoxycarbonyl(Methyl)Amino)-3-Methoxy-5-Methylheptanoic Acid
CAS No.	132149-81-6
Molecular Formula	C15H29NO5
Molecular Weight	303.40 g/mol
Synonyms	Boc-N(Me)-3-Methoxy-5-Methyl-D-homoPhe-OH; (3R,4S,5S)-4-[[(1,1-Dimethylethoxy)carbonyl](methyl)amino]-3-methoxy-5-methylheptanoic Acid; Boc-N-methyl-3-methoxy-5-methyl-D-homophenylalanine; N-Boc-N-methyl-3-methoxy-5-methyl-D-homophenylalanine; (3R,4S,5S)-4-[(tert-Butoxycarbonyl)(methyl)amino]-3-methoxy-5-methylheptanoic Acid; 132149-81-6; tert-Butyl (3R,4S,5S)-3-methoxy-5-methyl-4-(methylcarbamoyl)heptanoate (related ester)
EINECS	Contact for details

Quality Control

Our production of (3R,4S,5S)-4-(tert-Butoxycarbonyl(Methyl)Amino)-3-Methoxy-5-Methylheptanoic Acid adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling by HPLC, to ensure compliance with exacting standards for pharmaceutical-grade intermediates. Certificates of Analysis (COA) detailing identity, purity, and specific test results are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.