Description

4-Isoxazolecarboxylicacid,5-Amino-3-(Trifluoromethyl)-(9Ci) is a specialized heterocyclic building block containing both an amino group and a carboxylic acid functional group on an isoxazole core. This unique trifluoromethyl-substituted structure makes it a valuable intermediate for the synthesis of novel pharmaceuticals and agrochemicals, where it can impart enhanced metabolic stability and bioavailability. It is primarily sought after by research and development chemists in the pharmaceutical, agrochemical, and advanced material sectors for creating new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group can improve lipophilicity and biological activity.
• Chemical Biology & Proteomics: Serves as a versatile scaffold for designing enzyme inhibitors, activity-based probes, and other tools for biochemical research.
• Material Science Research: Employed in the development of novel polymers, ligands for catalysis, and organic electronic materials due to its rigid heterocyclic structure and functional handles.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds for client projects.

Basic Information

Product Name	4-Isoxazolecarboxylicacid,5-Amino-3-(Trifluoromethyl)-(9Ci)
CAS No.	132066-38-7
Molecular Formula	C5H3F3N2O3
Molecular Weight	196.09 g/mol
Synonyms	5-Amino-3-(trifluoromethyl)isoxazole-4-carboxylic acid; 3-(Trifluoromethyl)-5-aminoisoxazole-4-carboxylic acid; 4-Isoxazolecarboxylic acid, 5-amino-3-(trifluoromethyl)-; 5-Amino-3-trifluoromethyl-4-isoxazolecarboxylic acid; 132066-38-7; AI3-52000; ZINC000003799755; SCHEMBL11806279; BCP14633; 5-Amino-3-(trifluoromethyl)-1,2-oxazole-4-carboxylic acid
EINECS	Contact for details

Quality Control

Our 4-Isoxazolecarboxylicacid,5-Amino-3-(Trifluoromethyl)-(9Ci) is produced under strict quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and synthesis applications. Certificates of Analysis (COA) detailing all specifications are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.