Description

1H-Isoindole-1,3(2H)-Dione, 2-[2-[4-(6-Fluoro-1,2-Benzisoxazol-3-Yl)-1-Piperidinyl]Ethyl]- is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is critical for the synthesis of active pharmaceutical ingredients (APIs) targeting specific neurological pathways. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development and production of modern psychotropic medications. Our supply ensures consistent quality and reliable availability for critical R&D and scale-up processes.

Application

• Key Intermediate in Atypical Antipsychotic Synthesis: Serves as a crucial building block in the manufacturing chain for modern antipsychotic drugs.
• Pharmaceutical Research & Development (R&D): Used in medicinal chemistry for the discovery and optimization of new central nervous system (CNS) active compounds.
• Process Chemistry & Scale-Up: Employed in pilot plant and commercial-scale API production under current Good Manufacturing Practices (cGMP).
• Reference Standard: Can be supplied as a high-purity standard for analytical method development and quality control in pharmaceutical labs.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for proprietary drug production.
• Academic Research: Used in university and institutional studies focusing on neuropharmacology and organic synthesis methodologies.

Basic Information

Item	Details
Product Name	1H-Isoindole-1,3(2H)-Dione, 2-[2-[4-(6-Fluoro-1,2-Benzisoxazol-3-Yl)-1-Piperidinyl]Ethyl]-
CAS No.	131999-28-5
Molecular Formula	C22H20FN3O3
Molecular Weight	393.42 g/mol
Synonyms	2-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-1H-isoindole-1,3(2H)-dione; 6-Fluoro-3-(4-(2-(1,3-dioxoisoindolin-2-yl)ethyl)piperidin-1-yl)-1,2-benzisoxazole; Risperidone Impurity; Risperidone Intermediate; Paliperidone Related Compound; Benzisoxazole Piperidine Derivative; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Every batch of this pharmaceutical intermediate is produced and tested to meet stringent quality standards suitable for use in drug substance synthesis. Our rigorous quality control protocol includes identity confirmation, purity assay, and controlled limits for specified impurities. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment to ensure full traceability and compliance with your quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any individual impurity ≤ 0.5% Total impurities ≤ 1.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.