Description

α-((2-(Dimethylamino)Ethoxy)Methyl)-4-Fluorobenzenemethanol Hydrochloride is a high-purity, non-nucleoside reverse transcriptase inhibitor (NNRTI) intermediate of significant pharmaceutical importance. This compound is a critical building block in the synthesis of Efavirenz, a key active pharmaceutical ingredient (API) used in antiretroviral therapy for the treatment of HIV-1. It is essential for pharmaceutical R&D laboratories, API manufacturers, and contract research organizations (CROs) engaged in the development and production of advanced antiviral medications.

Application

• Primary Intermediate for Efavirenz Synthesis: Serves as the crucial chiral precursor in the multi-step manufacturing process of the antiretroviral drug Efavirenz (CAS 154598-52-4).
• Pharmaceutical Research & Development: Used in process development, route scouting, and scale-up studies for next-generation NNRTI-based therapies.
• Active Pharmaceutical Ingredient (API) Manufacturing: A key raw material in cGMP-compliant production lines for antiviral APIs, ensuring supply chain reliability for finished dosage forms.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development and impurity profiling.
• Contract Synthesis: Supplied to custom synthesis and toll manufacturing facilities specializing in complex, chiral pharmaceutical intermediates.

Basic Information

Product Name	α-((2-(Dimethylamino)Ethoxy)Methyl)-4-Fluorobenzenemethanol Hydrochloride
CAS No.	131961-44-9
Molecular Formula	C₁₂H₁₉ClFNO₂
Molecular Weight	263.74 g/mol
Synonyms	(S)-α-[(2-(Dimethylamino)ethoxy)methyl]-4-fluorobenzenemethanol hydrochloride; (S)-6-Chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one intermediate; Efavirenz Intermediate; DMP 266 Intermediate; L-743,726 Intermediate; (+)-(S)-α-[(2-(Dimethylamino)ethoxy)methyl]-4-fluorobenzenemethanol hydrochloride; 4-Fluoro-α-[(2-(dimethylamino)ethoxy)methyl]benzenemethanol hydrochloride
EINECS	Contact for details

Quality Control

Our α-((2-(Dimethylamino)Ethoxy)Methyl)-4-Fluorobenzenemethanol Hydrochloride is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including chiral purity determination by HPLC, to ensure compliance with stringent pharmaceutical intermediate specifications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator to prevent degradation upon exposure to air.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Chiral Purity (HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.