Description

1-(tert-Butoxycarbonyl)-5-Hydroxypiperidine-2-Carboxylic Acid is a versatile and high-purity Boc-protected piperidine derivative, serving as a critical chiral building block in advanced organic synthesis. Its value lies in providing a protected amine and carboxylic acid functionality, enabling precise and efficient construction of complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries, particularly for developing active pharmaceutical ingredients (APIs) and novel bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Peptidomimetics & Constrained Peptides: Used to introduce constrained piperidine scaffolds into peptide backbones to enhance metabolic stability and bioavailability.
• Protease Inhibitor Development: Serves as a core structural element in the design and synthesis of inhibitors for various protease enzymes.
• Chemical Biology & Probe Synthesis: Employed in the creation of molecular probes and tool compounds for studying biological pathways and target engagement.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or starting material in stereoselective reactions to create enantiomerically pure compounds.
• Custom Synthesis & Contract Manufacturing: A fundamental building block supplied for custom synthesis projects and development-scale manufacturing.

Basic Information

Product Name	1-(tert-Butoxycarbonyl)-5-Hydroxypiperidine-2-Carboxylic Acid
CAS No.	131950-00-0
Molecular Formula	C11H19NO5
Molecular Weight	245.27 g/mol
Synonyms	5-Hydroxy-2-piperidinecarboxylic acid 1-(1,1-dimethylethyl) ester; 1-Boc-5-hydroxypipecolic acid; (2S)-1-[(2-Methylpropan-2-yl)oxycarbonyl]-5-hydroxypiperidine-2-carboxylic acid; 1-N-Boc-5-hydroxypipecolic acid; 5-Hydroxy-1-Boc-pipecolic acid; Boc-5-Hydroxy-DL-pipecolic acid; tert-Butyl 5-hydroxy-2-carboxypiperidine-1-carboxylate
EINECS	Contact for details

Quality Control

Every batch of 1-(tert-Butoxycarbonyl)-5-Hydroxypiperidine-2-Carboxylic Acid is manufactured under a strict quality management system and undergoes comprehensive analytical testing. We ensure compliance with stringent internal specifications suitable for research and development use. A detailed Certificate of Analysis (COA), including chiral purity data, is provided with each shipment to guarantee product identity, purity, and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Chiral Purity (Chiral HPLC)	≥98.0% ee
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.