Description

1,4,7,10-Tetraazacyclododecane-1,4,7-Triacetic Acid, Trimethyl Ester is a key chemical intermediate and a protected derivative of the versatile macrocyclic chelator DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid). This compound is critical for the controlled synthesis of high-purity metal chelates and radiopharmaceuticals, where its ester groups allow for selective functionalization. It is primarily required by researchers and manufacturers in the pharmaceutical, diagnostic imaging, and advanced materials sectors for developing targeted contrast agents and therapeutic radiopharmaceuticals.

Application

• Radiopharmaceutical Precursor: A crucial building block for synthesizing DOTA-based chelators used in Positron Emission Tomography (PET) and Single-Photon Emission Computed Tomography (SPECT) imaging agents.
• Therapeutic Agent Synthesis: Used in the development of targeted radionuclide therapy (TRT) compounds for cancer treatment, such as those using Lutetium-177 or Actinium-225.
• Contrast Agent Intermediate: Serves as a protected intermediate in the multi-step synthesis of Gadolinium-based MRI contrast agents.
• Chemical Research & Development: Employed in academic and industrial R&D for studying macrocyclic chemistry and developing novel metal-organic complexes.
• Bioconjugation Linker: The ester groups can be modified to create reactive sites for attaching targeting biomolecules like antibodies or peptides.
• Catalyst Ligand Synthesis: Acts as a precursor for creating specialized ligands used in homogeneous catalysis and material science.

Basic Information

Item	Details
Product Name	1,4,7,10-Tetraazacyclododecane-1,4,7-Triacetic Acid, Trimethyl Ester
CAS No.	131934-31-1
Molecular Formula	C17H30N4O6
Molecular Weight	386.45 g/mol
Synonyms	DOTA-Tris(methyl ester); 1,4,7-Tris(carboxymethyl)-10-(methoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane; Trimethyl 1,4,7,10-tetraazacyclododecane-1,4,7-triacetate; DOTA-tris(OMe); DOTA Tri-Me Ester; 1,4,7-Tris(methoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane; Cyclen triacetic acid trimethyl ester
EINECS	Contact for details

Quality Control

Our 1,4,7,10-Tetraazacyclododecane-1,4,7-Triacetic Acid, Trimethyl Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and performance. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.