Description

4-Hydroxy Lansoprazole Sulfide is a key pharmaceutical intermediate and metabolite of the proton pump inhibitor Lansoprazole. This compound matters for its critical role in the research, development, and quality control of anti-ulcerative medications. It is primarily needed by pharmaceutical R&D laboratories, API manufacturers, and analytical service providers engaged in metabolic studies, impurity profiling, and the synthesis of advanced therapeutic agents.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of Lansoprazole and related proton pump inhibitor drugs.
• Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control in pharmaceutical testing.
• Metabolite Studies: Essential for pharmacokinetic and pharmacodynamic research to understand the metabolic pathway and bioavailability of Lansoprazole.
• Impurity Profiling: Serves as a known impurity standard to monitor and control the quality of Lansoprazole Active Pharmaceutical Ingredient (API) during manufacturing.
• Academic & Contract Research: Utilized in university and CRO settings for medicinal chemistry research and drug discovery programs focused on gastroesophageal therapies.

Basic Information

Product Name	4-Hydroxy Lansoprazole Sulfide
CAS No.	131926-95-9
Molecular Formula	C16H14F3N3O2S
Molecular Weight	369.36 g/mol
Synonyms	2-[[[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazol-5-ol; Lansoprazole Sulfide Hydroxy Analog; 5-Hydroxy Lansoprazole Sulfide; AG-1812; Metabolite of Lansoprazole; 4-Hydroxy AG-1749; 4-OH Lansoprazole Sulfide
EINECS	Contact for details

Quality Control

Our 4-Hydroxy Lansoprazole Sulfide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR, to ensure it meets the high standards required for pharmaceutical development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.