Description

(11β,16α)-21-(Acetyloxy)-9-Fluoro-11,16,17-Trihydroxy-Pregna-1,4,14-Triene-3,20-Dione is a high-purity synthetic steroid derivative, specifically a fluorinated glucocorticoid, valued for its potent anti-inflammatory and immunosuppressive activity. This compound serves as a critical pharmaceutical reference standard and advanced intermediate in the research and development of novel corticosteroid-based therapeutics. It is essential for pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions focused on endocrinology, immunology, and drug discovery.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potent topical and systemic corticosteroid drugs.
• Reference Standard: Used for analytical method development, validation, and quality control (QC) in pharmaceutical manufacturing to ensure product identity and purity.
• Biochemical Research: Employed in in vitro and in vivo studies to investigate glucocorticoid receptor (GR) binding, gene expression modulation, and anti-inflammatory pathways.
• Metabolite Studies: Utilized as a standard in pharmacokinetic and metabolic stability studies for related corticosteroid compounds.
• Veterinary Medicine Development: Applied in the R&D of anti-inflammatory treatments for animals.
• Impurity Profiling: Serves as a marker or impurity standard in the analysis of related steroid APIs to meet ICH guidelines.

Basic Information

Item	Details
Product Name	(11β,16α)-21-(Acetyloxy)-9-Fluoro-11,16,17-Trihydroxy-Pregna-1,4,14-Triene-3,20-Dione
CAS No.	131918-74-6
Molecular Formula	C23H27FO7
Molecular Weight	434.46 g/mol
Synonyms	9-Fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione 21-acetate; Fluocinolone Acetonide Related Compound C; 9α-Fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione 21-acetate; 21-Acetoxy-9-fluoro-11β,16α,17-trihydroxypregna-1,4,14-triene-3,20-dione; Fluocinolone Acetonide EP Impurity C; Fluocinolone Acetonide Impurity C; (11β,16α)-21-(Acetyloxy)-9-fluoro-11,16,17-trihydroxypregna-1,4,14-triene-3,20-dione
EINECS	Contact for details

Quality Control

Our (11β,16α)-21-(Acetyloxy)-9-Fluoro-11,16,17-Trihydroxy-Pregna-1,4,14-Triene-3,20-Dione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets high-grade specifications suitable for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing purity, related substances, and residual solvents is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.